Biomonitoring of Serum Inorganic Element Concentrations in Morbidly Obese Patients: Impact of Bariatric Surgery
Adipose tissue, in addition to serving as energy storage, can store lipophilic substances, some of which may pose a health risk if massively mobilized during rapid weight loss. This study aimed to biomonitor inorganic elements in obese patients undergoing bariatric surgery and analyze the role of so...
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MDPI AG
2025-02-01
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| Online Access: | https://www.mdpi.com/2305-6304/13/3/152 |
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| author | Álvaro Ramos-Luzardo Pilar Fernández Valerón Beatriz Vanessa Díaz-González Manuel Zumbado Katherine Simbaña-Rivera Inmaculada Bautista-Castaño Norberto Ruiz-Suárez Elisabeth Hernández-García Judith Cornejo-Torre Octavio P. Luzardo Lluis Serra-Majem Luis Alberto Henríquez-Hernández |
| author_facet | Álvaro Ramos-Luzardo Pilar Fernández Valerón Beatriz Vanessa Díaz-González Manuel Zumbado Katherine Simbaña-Rivera Inmaculada Bautista-Castaño Norberto Ruiz-Suárez Elisabeth Hernández-García Judith Cornejo-Torre Octavio P. Luzardo Lluis Serra-Majem Luis Alberto Henríquez-Hernández |
| author_sort | Álvaro Ramos-Luzardo |
| collection | DOAJ |
| description | Adipose tissue, in addition to serving as energy storage, can store lipophilic substances, some of which may pose a health risk if massively mobilized during rapid weight loss. This study aimed to biomonitor inorganic elements in obese patients undergoing bariatric surgery and analyze the role of sociodemographic factors. ICP-MS was employed to quantify 55 elements, including elements identified from the ATSDR’s Substance Priority List and rare-earth elements, in serum samples of 58 obese patients before and after bariatric surgery. A total of 39 out of 55 elements were detected, either before or after surgery, in at least one patient. Serum concentrations of gold, copper, mercury, platinum, and selenium significantly decreased after surgery. Serum concentrations of iron and zinc were significantly lower before surgery. Age, sex, diabetes status, arterial hypertension, and family history of obesity were demographic factors associated with the concentration of elements. Correlation analyses showed significant associations between elements and total lipid concentration or body mass index. Our findings indicate a complex interplay between inorganic elements and body fat and provide relevant information regarding the biomonitoring of these chemical elements in a specific and understudied population. |
| format | Article |
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| institution | OA Journals |
| issn | 2305-6304 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj-art-9e548043f1eb4872a7c20555d12529fa2025-08-20T01:48:46ZengMDPI AGToxics2305-63042025-02-0113315210.3390/toxics13030152Biomonitoring of Serum Inorganic Element Concentrations in Morbidly Obese Patients: Impact of Bariatric SurgeryÁlvaro Ramos-Luzardo0Pilar Fernández Valerón1Beatriz Vanessa Díaz-González2Manuel Zumbado3Katherine Simbaña-Rivera4Inmaculada Bautista-Castaño5Norberto Ruiz-Suárez6Elisabeth Hernández-García7Judith Cornejo-Torre8Octavio P. Luzardo9Lluis Serra-Majem10Luis Alberto Henríquez-Hernández11Department of Biochemistry and Molecular Biology, Physiology, Genetics, and Immunology, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainDepartment of Biochemistry and Molecular Biology, Physiology, Genetics, and Immunology, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainResearch Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainToxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainToxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, SpainToxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainResearch Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainResearch Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainToxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainResearch Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainToxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainAdipose tissue, in addition to serving as energy storage, can store lipophilic substances, some of which may pose a health risk if massively mobilized during rapid weight loss. This study aimed to biomonitor inorganic elements in obese patients undergoing bariatric surgery and analyze the role of sociodemographic factors. ICP-MS was employed to quantify 55 elements, including elements identified from the ATSDR’s Substance Priority List and rare-earth elements, in serum samples of 58 obese patients before and after bariatric surgery. A total of 39 out of 55 elements were detected, either before or after surgery, in at least one patient. Serum concentrations of gold, copper, mercury, platinum, and selenium significantly decreased after surgery. Serum concentrations of iron and zinc were significantly lower before surgery. Age, sex, diabetes status, arterial hypertension, and family history of obesity were demographic factors associated with the concentration of elements. Correlation analyses showed significant associations between elements and total lipid concentration or body mass index. Our findings indicate a complex interplay between inorganic elements and body fat and provide relevant information regarding the biomonitoring of these chemical elements in a specific and understudied population.https://www.mdpi.com/2305-6304/13/3/152obesitybariatric surgeryinorganic elementsheavy metalsrare-earth elementsweight loss |
| spellingShingle | Álvaro Ramos-Luzardo Pilar Fernández Valerón Beatriz Vanessa Díaz-González Manuel Zumbado Katherine Simbaña-Rivera Inmaculada Bautista-Castaño Norberto Ruiz-Suárez Elisabeth Hernández-García Judith Cornejo-Torre Octavio P. Luzardo Lluis Serra-Majem Luis Alberto Henríquez-Hernández Biomonitoring of Serum Inorganic Element Concentrations in Morbidly Obese Patients: Impact of Bariatric Surgery Toxics obesity bariatric surgery inorganic elements heavy metals rare-earth elements weight loss |
| title | Biomonitoring of Serum Inorganic Element Concentrations in Morbidly Obese Patients: Impact of Bariatric Surgery |
| title_full | Biomonitoring of Serum Inorganic Element Concentrations in Morbidly Obese Patients: Impact of Bariatric Surgery |
| title_fullStr | Biomonitoring of Serum Inorganic Element Concentrations in Morbidly Obese Patients: Impact of Bariatric Surgery |
| title_full_unstemmed | Biomonitoring of Serum Inorganic Element Concentrations in Morbidly Obese Patients: Impact of Bariatric Surgery |
| title_short | Biomonitoring of Serum Inorganic Element Concentrations in Morbidly Obese Patients: Impact of Bariatric Surgery |
| title_sort | biomonitoring of serum inorganic element concentrations in morbidly obese patients impact of bariatric surgery |
| topic | obesity bariatric surgery inorganic elements heavy metals rare-earth elements weight loss |
| url | https://www.mdpi.com/2305-6304/13/3/152 |
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