New insights into microbial bile salt hydrolases: from physiological roles to potential applications
Gut microbiota has been increasingly linked to metabolic health and diseases over the past few decades. Bile acids (BAs), the major components of bile, are bidirectionally linked to intestinal microbiota, also known as the gut microbiome-BA metabolic axis. Gut microbiota-derived bile salt hydrolase...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1513541/full |
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| author | Zixing Dong Shuangshuang Yang Cunduo Tang Dandan Li Dandan Li Yunchao Kan Yunchao Kan Lunguang Yao Lunguang Yao |
| author_facet | Zixing Dong Shuangshuang Yang Cunduo Tang Dandan Li Dandan Li Yunchao Kan Yunchao Kan Lunguang Yao Lunguang Yao |
| author_sort | Zixing Dong |
| collection | DOAJ |
| description | Gut microbiota has been increasingly linked to metabolic health and diseases over the past few decades. Bile acids (BAs), the major components of bile, are bidirectionally linked to intestinal microbiota, also known as the gut microbiome-BA metabolic axis. Gut microbiota-derived bile salt hydrolase (BSH, EC 3.5.1.24), which catalyzes the “gateway” reaction in a wider pathway of bile acid modification, not only shapes the bile acid landscape, but also modulates the crosstalk between gut microbiota and host health. Therefore, microbial BSHs exhibit the potential to directly or indirectly influence microbial and host physiologies, and have been increasingly considered as promising targets for the modulation of gut microbiota to benefit animal and human health. However, their physiological functions in bacterial and host physiologies are still controversial and not clear. In this review, we mainly discuss the current evidence related to the physiological roles that BSHs played in gut microbiota and human health, and the possible underlying mechanisms. Meanwhile, we also present the potential applications of BSHs and BSH-producing probiotics in various fields. Finally, we describe several important questions that need to be addressed by further investigations. A detailed exploration of the physiological significance of BSHs will contribute to their future diagnostic and therapeutic applications in improving animal and human health. |
| format | Article |
| id | doaj-art-9e53097a99674d6e9ebbc0d08ae5e286 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-9e53097a99674d6e9ebbc0d08ae5e2862025-02-12T07:25:46ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-02-011610.3389/fmicb.2025.15135411513541New insights into microbial bile salt hydrolases: from physiological roles to potential applicationsZixing Dong0Shuangshuang Yang1Cunduo Tang2Dandan Li3Dandan Li4Yunchao Kan5Yunchao Kan6Lunguang Yao7Lunguang Yao8Henan Province Engineering Research Center of Insect Bioreactor, College of Life Sciences, Nanyang Normal University, Nanyang, ChinaCollege of Physical Education, Nanyang Normal University, Nanyang, ChinaHenan Province Engineering Research Center of Insect Bioreactor, College of Life Sciences, Nanyang Normal University, Nanyang, ChinaHenan Province Engineering Research Center of Insect Bioreactor, College of Life Sciences, Nanyang Normal University, Nanyang, ChinaChina-UK-NYNU-RRes Joint Laboratory of Insect Biology, Henan Key Laboratory of Insect Biology in Funiu Mountain, Nanyang Normal University, Nanyang, ChinaHenan Province Engineering Research Center of Insect Bioreactor, College of Life Sciences, Nanyang Normal University, Nanyang, ChinaChina-UK-NYNU-RRes Joint Laboratory of Insect Biology, Henan Key Laboratory of Insect Biology in Funiu Mountain, Nanyang Normal University, Nanyang, ChinaHenan Province Engineering Research Center of Insect Bioreactor, College of Life Sciences, Nanyang Normal University, Nanyang, ChinaChina-UK-NYNU-RRes Joint Laboratory of Insect Biology, Henan Key Laboratory of Insect Biology in Funiu Mountain, Nanyang Normal University, Nanyang, ChinaGut microbiota has been increasingly linked to metabolic health and diseases over the past few decades. Bile acids (BAs), the major components of bile, are bidirectionally linked to intestinal microbiota, also known as the gut microbiome-BA metabolic axis. Gut microbiota-derived bile salt hydrolase (BSH, EC 3.5.1.24), which catalyzes the “gateway” reaction in a wider pathway of bile acid modification, not only shapes the bile acid landscape, but also modulates the crosstalk between gut microbiota and host health. Therefore, microbial BSHs exhibit the potential to directly or indirectly influence microbial and host physiologies, and have been increasingly considered as promising targets for the modulation of gut microbiota to benefit animal and human health. However, their physiological functions in bacterial and host physiologies are still controversial and not clear. In this review, we mainly discuss the current evidence related to the physiological roles that BSHs played in gut microbiota and human health, and the possible underlying mechanisms. Meanwhile, we also present the potential applications of BSHs and BSH-producing probiotics in various fields. Finally, we describe several important questions that need to be addressed by further investigations. A detailed exploration of the physiological significance of BSHs will contribute to their future diagnostic and therapeutic applications in improving animal and human health.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1513541/fullgut microbiotahost healthbile acidsbile salt hydrolasephysiological rolespotential applications |
| spellingShingle | Zixing Dong Shuangshuang Yang Cunduo Tang Dandan Li Dandan Li Yunchao Kan Yunchao Kan Lunguang Yao Lunguang Yao New insights into microbial bile salt hydrolases: from physiological roles to potential applications Frontiers in Microbiology gut microbiota host health bile acids bile salt hydrolase physiological roles potential applications |
| title | New insights into microbial bile salt hydrolases: from physiological roles to potential applications |
| title_full | New insights into microbial bile salt hydrolases: from physiological roles to potential applications |
| title_fullStr | New insights into microbial bile salt hydrolases: from physiological roles to potential applications |
| title_full_unstemmed | New insights into microbial bile salt hydrolases: from physiological roles to potential applications |
| title_short | New insights into microbial bile salt hydrolases: from physiological roles to potential applications |
| title_sort | new insights into microbial bile salt hydrolases from physiological roles to potential applications |
| topic | gut microbiota host health bile acids bile salt hydrolase physiological roles potential applications |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1513541/full |
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