Conformational Study of n,n’-(Alkane-1,n-diyl)bis(2-phenyl-3,5-dihydro-4<i>H</i>-imidazol-4-one)s with Different Spacer Length
In this study, we investigated the conformational abilities of n,n’-(Alkanediyl)-bis(2-phenyl-3,5-dihydro-4<i>H</i>-imidazol-4-one)s (<b>1</b>) to gain insight into their biological potential as a platform for the generation of various QACs. Among the conformers of <b>1...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
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| Series: | Chemistry Proceedings |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4583/14/1/6 |
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| Summary: | In this study, we investigated the conformational abilities of n,n’-(Alkanediyl)-bis(2-phenyl-3,5-dihydro-4<i>H</i>-imidazol-4-one)s (<b>1</b>) to gain insight into their biological potential as a platform for the generation of various QACs. Among the conformers of <b>1</b>, due to the flexibility of the polymethylene fragment, the phenyl rings can take on different mutual arrangements, while there is a clear tendency for the formation of π–π interactions. From the point of view of the reactivity to alkylating agents, a preliminary conclusion can be drawn about the favorable mutual arrangement of imidazolone rings located at a sufficient distance to carry out both mono- and bisalkylation to obtain bis-QAC. |
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| ISSN: | 2673-4583 |