Strain and Vibration in Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into any mesenchymal tissue, including bone, cartilage, muscle, and fat. MSC differentiation can be influenced by a variety of stimuli, including environmental and mechanical stimulation, scaffold physical properties, or...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2018/8686794 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850170293272707072 |
|---|---|
| author | Brooke McClarren Ronke Olabisi |
| author_facet | Brooke McClarren Ronke Olabisi |
| author_sort | Brooke McClarren |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into any mesenchymal tissue, including bone, cartilage, muscle, and fat. MSC differentiation can be influenced by a variety of stimuli, including environmental and mechanical stimulation, scaffold physical properties, or applied loads. Numerous studies have evaluated the effects of vibration or cyclic tensile strain on MSCs towards developing a mechanically based method of differentiation, but there is no consensus between studies and each investigation uses different culture conditions, which also influence MSC fate. Here we present an overview of the response of MSCs to vibration and cyclic tension, focusing on the effect of various culture conditions and strain or vibration parameters. Our review reveals that scaffold type (e.g., natural versus synthetic; 2D versus 3D) can influence cell response to vibration and strain to the same degree as loading parameters. Hence, in the efforts to use mechanical loading as a reliable method to differentiate cells, scaffold selection is as important as method of loading. |
| format | Article |
| id | doaj-art-9e4a707042b04ea08fa7bb97b446ff02 |
| institution | OA Journals |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-9e4a707042b04ea08fa7bb97b446ff022025-08-20T02:20:30ZengWileyInternational Journal of Biomaterials1687-87871687-87952018-01-01201810.1155/2018/86867948686794Strain and Vibration in Mesenchymal Stem CellsBrooke McClarren0Ronke Olabisi1Department of Biomedical Engineering, Rutgers University, 599 Taylor Rd, Piscataway, NJ 08854, USADepartment of Biomedical Engineering, Rutgers University, 599 Taylor Rd, Piscataway, NJ 08854, USAMesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into any mesenchymal tissue, including bone, cartilage, muscle, and fat. MSC differentiation can be influenced by a variety of stimuli, including environmental and mechanical stimulation, scaffold physical properties, or applied loads. Numerous studies have evaluated the effects of vibration or cyclic tensile strain on MSCs towards developing a mechanically based method of differentiation, but there is no consensus between studies and each investigation uses different culture conditions, which also influence MSC fate. Here we present an overview of the response of MSCs to vibration and cyclic tension, focusing on the effect of various culture conditions and strain or vibration parameters. Our review reveals that scaffold type (e.g., natural versus synthetic; 2D versus 3D) can influence cell response to vibration and strain to the same degree as loading parameters. Hence, in the efforts to use mechanical loading as a reliable method to differentiate cells, scaffold selection is as important as method of loading.http://dx.doi.org/10.1155/2018/8686794 |
| spellingShingle | Brooke McClarren Ronke Olabisi Strain and Vibration in Mesenchymal Stem Cells International Journal of Biomaterials |
| title | Strain and Vibration in Mesenchymal Stem Cells |
| title_full | Strain and Vibration in Mesenchymal Stem Cells |
| title_fullStr | Strain and Vibration in Mesenchymal Stem Cells |
| title_full_unstemmed | Strain and Vibration in Mesenchymal Stem Cells |
| title_short | Strain and Vibration in Mesenchymal Stem Cells |
| title_sort | strain and vibration in mesenchymal stem cells |
| url | http://dx.doi.org/10.1155/2018/8686794 |
| work_keys_str_mv | AT brookemcclarren strainandvibrationinmesenchymalstemcells AT ronkeolabisi strainandvibrationinmesenchymalstemcells |