Biological evaluation of semi-synthetic isoindolinone isomers produced by Stachybotrys chartarum

Biological evaluation of semi-synthetic isoindolinone isomers produced by Stachybotrys chartarum

The filamentous fungus Stachybotrys chartarum is rich in meroterpenoid secondary metabolites, some of which carry o-dialdehyde moieties, which are readily derivatized to isoindolinones by addition of primary amines. The structural diversity of phenylspirodrimanes, in particular, is linked to a wide...

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Bibliographic Details
Main Authors: Alica Fischle, Ulrich Schreiber, Viola Haupt, Felix Schimang, Lina Schürmann, Matthias Behrens, Florian Hübner, Melanie Esselen, Dmitrii V. Kalinin, Svetlana A. Kalinina
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Fungal Biology
Subjects:
semi-synthesis
regioisomerism
Stachybotrys
genotoxicity
biological activity
hepatic metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/ffunb.2024.1494795/full
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