Alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non-communicable diseases: a systematic review and meta-analysis using the GRADE approach
Abstract Background Inflammation and oxidative stress are key risk factors in noncommunicable diseases (NCDs). Probiotics have been suggested to be beneficial in mitigating inflammation and oxidative stress; however, the evidence remains inconsistent due to variations in study design, dosage, and pa...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Pharmacology and Toxicology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40360-025-00957-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849389264407625728 |
|---|---|
| author | Xiaoyuan Yu Li Yan Lingxiao Chen Xianmei Shen Wenzheng Zhang |
| author_facet | Xiaoyuan Yu Li Yan Lingxiao Chen Xianmei Shen Wenzheng Zhang |
| author_sort | Xiaoyuan Yu |
| collection | DOAJ |
| description | Abstract Background Inflammation and oxidative stress are key risk factors in noncommunicable diseases (NCDs). Probiotics have been suggested to be beneficial in mitigating inflammation and oxidative stress; however, the evidence remains inconsistent due to variations in study design, dosage, and patient populations. Methods Studies were included following a systematic search of PubMed, Scopus, Cochrane Library, Web of Science, and EMBASE, provided they fulfilled the eligibility criteria. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to clarify the effects of probiotics on oxidative stress and inflammation in non-communicable diseases (NCDs). Results A review of 18 studies revealed that probiotic supplementation significantly reduced CRP (SMD = -1.33, 95% CI: -1.84, -0.82; p < 0.001, high certainty), TNF-α (SMD = -1.10, 95% CI: -1.66, -0.55; p < 0.001, low certainty), and MDA levels (SMD = -1.38, 95% CI: -2.08, -0.69; p < 0.001, high certainty). Additionally, while probiotics increased GSH levels (SMD = 0.65, 95% CI: 0.06, 1.23; p < 0.001, high certainty), they did not change the levels of IL-6 (SMD = -1.05, 95% CI: -2.21, 0.11; p < 0.001, low certainty), NO (SMD = 0.47, 95% CI: -0.54, 1.48; p = 0.363, low certainty) and TAC levels (SMD = 0.24, 95% CI: -0.27, 0.74; p = 0.357, moderate certainty). Conclusion The supplementation of probiotics may have mitigated biomarkers associated with inflammation and oxidative stress. |
| format | Article |
| id | doaj-art-9e40f30cc67d4c5c9ffb49bd461a118d |
| institution | Kabale University |
| issn | 2050-6511 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pharmacology and Toxicology |
| spelling | doaj-art-9e40f30cc67d4c5c9ffb49bd461a118d2025-08-20T03:42:00ZengBMCBMC Pharmacology and Toxicology2050-65112025-07-0126111510.1186/s40360-025-00957-5Alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non-communicable diseases: a systematic review and meta-analysis using the GRADE approachXiaoyuan Yu0Li Yan1Lingxiao Chen2Xianmei Shen3Wenzheng Zhang4Emergency and Critical Care Center, Intensive Care Unit, Affiliated People’s Hospital, Zhejiang Provincial People’s Hospital, Hangzhou Medical CollegeDepartment of Geriatric Gastroenterology, Nanjing Medical UniversityDepartment of Geriatric Gastroenterology, Nanjing Medical UniversityObstetrics and Gynecology, Haining Hospital of Traditional Chinese Medicine (Haining Cancer Hospital)Emergency and Critical Care Center, Intensive Care Unit, Affiliated People’s Hospital, Zhejiang Provincial People’s Hospital, Hangzhou Medical CollegeAbstract Background Inflammation and oxidative stress are key risk factors in noncommunicable diseases (NCDs). Probiotics have been suggested to be beneficial in mitigating inflammation and oxidative stress; however, the evidence remains inconsistent due to variations in study design, dosage, and patient populations. Methods Studies were included following a systematic search of PubMed, Scopus, Cochrane Library, Web of Science, and EMBASE, provided they fulfilled the eligibility criteria. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to clarify the effects of probiotics on oxidative stress and inflammation in non-communicable diseases (NCDs). Results A review of 18 studies revealed that probiotic supplementation significantly reduced CRP (SMD = -1.33, 95% CI: -1.84, -0.82; p < 0.001, high certainty), TNF-α (SMD = -1.10, 95% CI: -1.66, -0.55; p < 0.001, low certainty), and MDA levels (SMD = -1.38, 95% CI: -2.08, -0.69; p < 0.001, high certainty). Additionally, while probiotics increased GSH levels (SMD = 0.65, 95% CI: 0.06, 1.23; p < 0.001, high certainty), they did not change the levels of IL-6 (SMD = -1.05, 95% CI: -2.21, 0.11; p < 0.001, low certainty), NO (SMD = 0.47, 95% CI: -0.54, 1.48; p = 0.363, low certainty) and TAC levels (SMD = 0.24, 95% CI: -0.27, 0.74; p = 0.357, moderate certainty). Conclusion The supplementation of probiotics may have mitigated biomarkers associated with inflammation and oxidative stress.https://doi.org/10.1186/s40360-025-00957-5ProbioticsInflammationTotal antioxidant capacityMeta-analysis |
| spellingShingle | Xiaoyuan Yu Li Yan Lingxiao Chen Xianmei Shen Wenzheng Zhang Alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non-communicable diseases: a systematic review and meta-analysis using the GRADE approach BMC Pharmacology and Toxicology Probiotics Inflammation Total antioxidant capacity Meta-analysis |
| title | Alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non-communicable diseases: a systematic review and meta-analysis using the GRADE approach |
| title_full | Alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non-communicable diseases: a systematic review and meta-analysis using the GRADE approach |
| title_fullStr | Alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non-communicable diseases: a systematic review and meta-analysis using the GRADE approach |
| title_full_unstemmed | Alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non-communicable diseases: a systematic review and meta-analysis using the GRADE approach |
| title_short | Alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non-communicable diseases: a systematic review and meta-analysis using the GRADE approach |
| title_sort | alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non communicable diseases a systematic review and meta analysis using the grade approach |
| topic | Probiotics Inflammation Total antioxidant capacity Meta-analysis |
| url | https://doi.org/10.1186/s40360-025-00957-5 |
| work_keys_str_mv | AT xiaoyuanyu alleviatingeffectsofprobioticsupplementationonbiomarkersofinflammationandoxidativestressinnoncommunicablediseasesasystematicreviewandmetaanalysisusingthegradeapproach AT liyan alleviatingeffectsofprobioticsupplementationonbiomarkersofinflammationandoxidativestressinnoncommunicablediseasesasystematicreviewandmetaanalysisusingthegradeapproach AT lingxiaochen alleviatingeffectsofprobioticsupplementationonbiomarkersofinflammationandoxidativestressinnoncommunicablediseasesasystematicreviewandmetaanalysisusingthegradeapproach AT xianmeishen alleviatingeffectsofprobioticsupplementationonbiomarkersofinflammationandoxidativestressinnoncommunicablediseasesasystematicreviewandmetaanalysisusingthegradeapproach AT wenzhengzhang alleviatingeffectsofprobioticsupplementationonbiomarkersofinflammationandoxidativestressinnoncommunicablediseasesasystematicreviewandmetaanalysisusingthegradeapproach |