Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity
To clarify effects of diet and body weight on prostate cancer development, three studies were undertaken using the TRAMP mouse model of this disease. In the first experiment, obesity was induced by injection of gold thioglucose (GTG). Age of prostate tumor detection (~33 wk) and death (~43 wk) was n...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/543970 |
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| author | Melissa J. L. Bonorden Michael E. Grossmann Sarah A. Ewing Olga P. Rogozina Amitabha Ray Katai J. Nkhata D. Joshua Liao Joseph P. Grande Margot P. Cleary |
| author_facet | Melissa J. L. Bonorden Michael E. Grossmann Sarah A. Ewing Olga P. Rogozina Amitabha Ray Katai J. Nkhata D. Joshua Liao Joseph P. Grande Margot P. Cleary |
| author_sort | Melissa J. L. Bonorden |
| collection | DOAJ |
| description | To clarify effects of diet and body weight on prostate cancer development, three studies were undertaken using the TRAMP mouse model of this disease. In the first experiment, obesity was induced by injection of gold thioglucose (GTG). Age of prostate tumor detection (~33 wk) and death (~43 wk) was not significantly different among the groups. In the second study, TRAMP-C2 cells were injected into syngeneic C57BL6 mice and tumor progression was evaluated in mice fed either high-fat or low-fat diets. The high fat fed mice had larger tumors than did the low-fat fed mice. In the third study, tumor development was followed in TRAMP mice fed a high fat diet from 6 weeks of age. There were no significant effects of body weight status or diet on tumor development among the groups. When the tumors were examined for the neuroendocrine marker synaptophysin, there was no correlation with either body weight or diet. However, there was a significant correlation of the expression of synaptophysin with earlier age to tumor detection and death. In summary, TRAMP-C2 cells grew faster when the mice were fed a high-fat diet. Further synaptophysin may be a marker of poor prognosis independent of weight and diet. |
| format | Article |
| id | doaj-art-9e3e9b5763a849bba5a257faa9b48d7e |
| institution | OA Journals |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-9e3e9b5763a849bba5a257faa9b48d7e2025-08-20T02:20:29ZengWileyProstate Cancer2090-31112090-312X2012-01-01201210.1155/2012/543970543970Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and ObesityMelissa J. L. Bonorden0Michael E. Grossmann1Sarah A. Ewing2Olga P. Rogozina3Amitabha Ray4Katai J. Nkhata5D. Joshua Liao6Joseph P. Grande7Margot P. Cleary8The Hormel Institute, University of Minnesota, Austin, MN 55912, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USADepartment of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USATo clarify effects of diet and body weight on prostate cancer development, three studies were undertaken using the TRAMP mouse model of this disease. In the first experiment, obesity was induced by injection of gold thioglucose (GTG). Age of prostate tumor detection (~33 wk) and death (~43 wk) was not significantly different among the groups. In the second study, TRAMP-C2 cells were injected into syngeneic C57BL6 mice and tumor progression was evaluated in mice fed either high-fat or low-fat diets. The high fat fed mice had larger tumors than did the low-fat fed mice. In the third study, tumor development was followed in TRAMP mice fed a high fat diet from 6 weeks of age. There were no significant effects of body weight status or diet on tumor development among the groups. When the tumors were examined for the neuroendocrine marker synaptophysin, there was no correlation with either body weight or diet. However, there was a significant correlation of the expression of synaptophysin with earlier age to tumor detection and death. In summary, TRAMP-C2 cells grew faster when the mice were fed a high-fat diet. Further synaptophysin may be a marker of poor prognosis independent of weight and diet.http://dx.doi.org/10.1155/2012/543970 |
| spellingShingle | Melissa J. L. Bonorden Michael E. Grossmann Sarah A. Ewing Olga P. Rogozina Amitabha Ray Katai J. Nkhata D. Joshua Liao Joseph P. Grande Margot P. Cleary Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity Prostate Cancer |
| title | Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity |
| title_full | Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity |
| title_fullStr | Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity |
| title_full_unstemmed | Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity |
| title_short | Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity |
| title_sort | growth and progression of tramp prostate tumors in relationship to diet and obesity |
| url | http://dx.doi.org/10.1155/2012/543970 |
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