Self-related thought alterations associated with intrinsic brain dysfunction in mild cognitive impairment
Abstract The subjective experience of self-awareness is attributed to the human capacity for introspective thought during periods of mind-wandering. However, how this cognitive function is impacted in individuals with mild cognitive impairment (MCI) still needs to be better understood. To address th...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-97240-8 |
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| author | Povilas Tarailis Kim Lory Paul G. Unschuld Christoph M. Michel Lucie Bréchet |
| author_facet | Povilas Tarailis Kim Lory Paul G. Unschuld Christoph M. Michel Lucie Bréchet |
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| description | Abstract The subjective experience of self-awareness is attributed to the human capacity for introspective thought during periods of mind-wandering. However, how this cognitive function is impacted in individuals with mild cognitive impairment (MCI) still needs to be better understood. To address this gap, we investigated alterations in self-referential thinking in a cohort of 30 MCI patients, comparing them to 60 healthy old-aged and 60 healthy younger controls. MCI patients exhibited a notable decline in overall cognitive function, as evidenced by significantly lower scores on the Montreal Cognitive Assessment (MoCA), with particular deficits in Memory subscore and Memory Index Score (MIS). Employing the Amsterdam Resting-State Questionnaire (ARSQ) to assess mind-wandering, we observed diminished self-related thoughts relating to personal past experiences and future thinking among MCI patients. Notably, using high-density electroencephalography (hdEEG) microstate analysis, we detected reduced neural activity for microstate C associated with self-related thoughts in MCI patients and healthy older relative to healthy younger controls, and an increase in neural activity for microstate A in MCI patients compared to healthy older and younger controls. This aberrant temporal activity was localized within brain regions implicated in episodic autobiographical memory and the default mode network. Our results highlight a link between impaired mind-wandering ability and dysfunction within the intrinsic neural networks of MCI patients, underscoring its implications for disruptions in the sense of self within this clinical population. |
| format | Article |
| id | doaj-art-9e3e0fbdbd5c44c9af277dcaea014c10 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-9e3e0fbdbd5c44c9af277dcaea014c102025-08-20T03:06:54ZengNature PortfolioScientific Reports2045-23222025-04-0115111310.1038/s41598-025-97240-8Self-related thought alterations associated with intrinsic brain dysfunction in mild cognitive impairmentPovilas Tarailis0Kim Lory1Paul G. Unschuld2Christoph M. Michel3Lucie Bréchet4Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of GenevaFunctional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of GenevaGeriatric Psychiatry Service University Hospitals of Geneva (HUG)Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of GenevaDepartment of Clinical Neurosciences, University of GenevaAbstract The subjective experience of self-awareness is attributed to the human capacity for introspective thought during periods of mind-wandering. However, how this cognitive function is impacted in individuals with mild cognitive impairment (MCI) still needs to be better understood. To address this gap, we investigated alterations in self-referential thinking in a cohort of 30 MCI patients, comparing them to 60 healthy old-aged and 60 healthy younger controls. MCI patients exhibited a notable decline in overall cognitive function, as evidenced by significantly lower scores on the Montreal Cognitive Assessment (MoCA), with particular deficits in Memory subscore and Memory Index Score (MIS). Employing the Amsterdam Resting-State Questionnaire (ARSQ) to assess mind-wandering, we observed diminished self-related thoughts relating to personal past experiences and future thinking among MCI patients. Notably, using high-density electroencephalography (hdEEG) microstate analysis, we detected reduced neural activity for microstate C associated with self-related thoughts in MCI patients and healthy older relative to healthy younger controls, and an increase in neural activity for microstate A in MCI patients compared to healthy older and younger controls. This aberrant temporal activity was localized within brain regions implicated in episodic autobiographical memory and the default mode network. Our results highlight a link between impaired mind-wandering ability and dysfunction within the intrinsic neural networks of MCI patients, underscoring its implications for disruptions in the sense of self within this clinical population.https://doi.org/10.1038/s41598-025-97240-8Healthy agingCognitive declineMCI patientsResting-state EEG microstatesSelf-related thought |
| spellingShingle | Povilas Tarailis Kim Lory Paul G. Unschuld Christoph M. Michel Lucie Bréchet Self-related thought alterations associated with intrinsic brain dysfunction in mild cognitive impairment Scientific Reports Healthy aging Cognitive decline MCI patients Resting-state EEG microstates Self-related thought |
| title | Self-related thought alterations associated with intrinsic brain dysfunction in mild cognitive impairment |
| title_full | Self-related thought alterations associated with intrinsic brain dysfunction in mild cognitive impairment |
| title_fullStr | Self-related thought alterations associated with intrinsic brain dysfunction in mild cognitive impairment |
| title_full_unstemmed | Self-related thought alterations associated with intrinsic brain dysfunction in mild cognitive impairment |
| title_short | Self-related thought alterations associated with intrinsic brain dysfunction in mild cognitive impairment |
| title_sort | self related thought alterations associated with intrinsic brain dysfunction in mild cognitive impairment |
| topic | Healthy aging Cognitive decline MCI patients Resting-state EEG microstates Self-related thought |
| url | https://doi.org/10.1038/s41598-025-97240-8 |
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