Impact of steroid dose and timing on efficacy of combination PD-1/CTLA-4 blockade

Impact of steroid dose and timing on efficacy of combination PD-1/CTLA-4 blockade

With the increasing use of immune checkpoint inhibitors (ICIs) in combination regimens and in earlier stages of advanced melanoma, the effective management of immune-related adverse events (irAEs) is key to balancing immunotherapy efficacy and toxicity. Conflicting evidence exists on possible detrim...

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Bibliographic Details
Main Authors: Nina B. Curkovic, Rebecca Irlmeier, Xue Bai, Can Cui, Fei Ye, Hannah R. Burnette, Aleigha R. Lawless, Juliane Andrade Czapla, Ryan Sullivan, Douglas B. Johnson
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Immune checkpoint inhibitor
immune-related adverse event - irAE
immunosuppression
immunotherapy
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2494433
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