Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration

Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration

Abstract Mitochondrial dysfunction and altered proteostasis are central features of neurodegenerative diseases. The pitrilysin metallopeptidase 1 (PITRM1) is a mitochondrial matrix enzyme, which digests oligopeptides, including the mitochondrial targeting sequences that are cleaved from proteins imp...

Full description

Saved in:
Bibliographic Details
Main Authors: Dario Brunetti, Janniche Torsvik, Cristina Dallabona, Pedro Teixeira, Pawel Sztromwasser, Erika Fernandez‐Vizarra, Raffaele Cerutti, Aurelio Reyes, Carmela Preziuso, Giulia D'Amati, Enrico Baruffini, Paola Goffrini, Carlo Viscomi, Ileana Ferrero, Helge Boman, Wenche Telstad, Stefan Johansson, Elzbieta Glaser, Per M Knappskog, Massimo Zeviani, Laurence A Bindoff
Format: Article
Language:English
Published: Springer Nature 2015-12-01
Series:EMBO Molecular Medicine
Subjects:
amyloid beta
mitochondrial targeting sequence
mitochondrial disease
neurodegeneration
pitrilysin 1
Online Access:https://doi.org/10.15252/emmm.201505894
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items