Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature
Background. Autoimmune hemolytic anemia (AIHA) associated with solid tumors such as mature cystic teratomas is rare and poorly understood. Here, we report a successfully treated case of secondary AIHA in a mature cystic teratoma containing antibodies against red blood cells. Case description. A 22-y...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2024/2223281 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548281894305792 |
|---|---|
| author | Yuma Nato Keiki Nagaharu Keika Itoh Naoki Shinke Keiko Maeyama Akihiko Sawaki Hiroyuki Miyashita |
| author_facet | Yuma Nato Keiki Nagaharu Keika Itoh Naoki Shinke Keiko Maeyama Akihiko Sawaki Hiroyuki Miyashita |
| author_sort | Yuma Nato |
| collection | DOAJ |
| description | Background. Autoimmune hemolytic anemia (AIHA) associated with solid tumors such as mature cystic teratomas is rare and poorly understood. Here, we report a successfully treated case of secondary AIHA in a mature cystic teratoma containing antibodies against red blood cells. Case description. A 22-year-old woman was referred to our hospital with progressive anemia. Laboratory findings revealed hemolysis with a positive direct and indirect antiglobulin test. Imaging studies identified a left ovarian mass, suspected to be a mature cystic teratoma, which was later confirmed by histopathology after laparoscopic oophorocystectomy. The patient was treated with prednisolone, resulting in improved anemia. To examine the relationship between the tumor and AIHA, an indirect antiglobulin test was performed on the tumor contents. Stronger aggregations were observed at any concentration diluted by 10 times from 10 to 10,000 times of the tumor contents compared to the patient’s serum. Additionally, immunofixation electrophoresis of the tumor contents revealed the presence of monoclonal immunoglobulin G-κ. Conclusion. The presence of monoclonal IgG-κ in the tumor suggests intratumoral antibody production as a possible mechanism. Further research is necessary to elucidate the pathogenic relationship between such tumors and AIHA. The report also highlights the importance of considering secondary AIHA in patients with unexplained anemia and solid tumors. |
| format | Article |
| id | doaj-art-9e34c7ee82df41fdac934ca49576d80c |
| institution | Kabale University |
| issn | 2090-6692 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-9e34c7ee82df41fdac934ca49576d80c2025-02-03T06:15:14ZengWileyCase Reports in Obstetrics and Gynecology2090-66922024-01-01202410.1155/2024/2223281Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of LiteratureYuma Nato0Keiki Nagaharu1Keika Itoh2Naoki Shinke3Keiko Maeyama4Akihiko Sawaki5Hiroyuki Miyashita6Department of HematologyDepartment of HematologyDivision of Blood TransfusionDepartment of HematologyDepartment of HematologyDepartment of HematologyDepartment of HematologyBackground. Autoimmune hemolytic anemia (AIHA) associated with solid tumors such as mature cystic teratomas is rare and poorly understood. Here, we report a successfully treated case of secondary AIHA in a mature cystic teratoma containing antibodies against red blood cells. Case description. A 22-year-old woman was referred to our hospital with progressive anemia. Laboratory findings revealed hemolysis with a positive direct and indirect antiglobulin test. Imaging studies identified a left ovarian mass, suspected to be a mature cystic teratoma, which was later confirmed by histopathology after laparoscopic oophorocystectomy. The patient was treated with prednisolone, resulting in improved anemia. To examine the relationship between the tumor and AIHA, an indirect antiglobulin test was performed on the tumor contents. Stronger aggregations were observed at any concentration diluted by 10 times from 10 to 10,000 times of the tumor contents compared to the patient’s serum. Additionally, immunofixation electrophoresis of the tumor contents revealed the presence of monoclonal immunoglobulin G-κ. Conclusion. The presence of monoclonal IgG-κ in the tumor suggests intratumoral antibody production as a possible mechanism. Further research is necessary to elucidate the pathogenic relationship between such tumors and AIHA. The report also highlights the importance of considering secondary AIHA in patients with unexplained anemia and solid tumors.http://dx.doi.org/10.1155/2024/2223281 |
| spellingShingle | Yuma Nato Keiki Nagaharu Keika Itoh Naoki Shinke Keiko Maeyama Akihiko Sawaki Hiroyuki Miyashita Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature Case Reports in Obstetrics and Gynecology |
| title | Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature |
| title_full | Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature |
| title_fullStr | Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature |
| title_full_unstemmed | Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature |
| title_short | Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature |
| title_sort | autoimmune hemolytic anemia associated with mature ovarian cystic teratoma containing monoclonal immunoglobulin g a case report and review of literature |
| url | http://dx.doi.org/10.1155/2024/2223281 |
| work_keys_str_mv | AT yumanato autoimmunehemolyticanemiaassociatedwithmatureovariancysticteratomacontainingmonoclonalimmunoglobulingacasereportandreviewofliterature AT keikinagaharu autoimmunehemolyticanemiaassociatedwithmatureovariancysticteratomacontainingmonoclonalimmunoglobulingacasereportandreviewofliterature AT keikaitoh autoimmunehemolyticanemiaassociatedwithmatureovariancysticteratomacontainingmonoclonalimmunoglobulingacasereportandreviewofliterature AT naokishinke autoimmunehemolyticanemiaassociatedwithmatureovariancysticteratomacontainingmonoclonalimmunoglobulingacasereportandreviewofliterature AT keikomaeyama autoimmunehemolyticanemiaassociatedwithmatureovariancysticteratomacontainingmonoclonalimmunoglobulingacasereportandreviewofliterature AT akihikosawaki autoimmunehemolyticanemiaassociatedwithmatureovariancysticteratomacontainingmonoclonalimmunoglobulingacasereportandreviewofliterature AT hiroyukimiyashita autoimmunehemolyticanemiaassociatedwithmatureovariancysticteratomacontainingmonoclonalimmunoglobulingacasereportandreviewofliterature |