A case report of breast Rosai-Dorfman disease and a literature review
Rosai-Dorfman disease (RDD) is a rare idiopathic histiocytoproliferative disease that usually affects the lymph nodes of the head and neck, but can also involve extranodal sites such as the skin, sinuses, and soft tissues. Breast RDD is exceedingly rare. It may be clinically and radiographically sim...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1474931/full |
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| author | Yuan Lin Ya-Wen Wang Li-Xin Li Zhong-Qi Qiao Zhong-Qi Qiao Xu Chen Yan-Duo Chen Can Liu Kai Zhang |
| author_facet | Yuan Lin Ya-Wen Wang Li-Xin Li Zhong-Qi Qiao Zhong-Qi Qiao Xu Chen Yan-Duo Chen Can Liu Kai Zhang |
| author_sort | Yuan Lin |
| collection | DOAJ |
| description | Rosai-Dorfman disease (RDD) is a rare idiopathic histiocytoproliferative disease that usually affects the lymph nodes of the head and neck, but can also involve extranodal sites such as the skin, sinuses, and soft tissues. Breast RDD is exceedingly rare. It may be clinically and radiographically similar to neoplastic and non-neoplastic diseases. We report a case of breast RDD in a 68-year-old female patient and describe the clinical imaging and pathological features of the patient. The management of extranodal RDD is individualized, and there are no standardized guidelines for treatment. We highlight the importance of considering the diagnosis of extranodal breast RDD, and suggest that surgical resection is an effective way to treat this disease, particularly for single-focal breast lesions with RDD. |
| format | Article |
| id | doaj-art-9e34abfb938546a29b8744c25bae8421 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-9e34abfb938546a29b8744c25bae84212025-08-20T03:12:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14749311474931A case report of breast Rosai-Dorfman disease and a literature reviewYuan Lin0Ya-Wen Wang1Li-Xin Li2Zhong-Qi Qiao3Zhong-Qi Qiao4Xu Chen5Yan-Duo Chen6Can Liu7Kai Zhang8Department of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Binzhou Second People’s Hospital, Binzhou, Shandong, ChinaDepartment of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Pediatric Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaRosai-Dorfman disease (RDD) is a rare idiopathic histiocytoproliferative disease that usually affects the lymph nodes of the head and neck, but can also involve extranodal sites such as the skin, sinuses, and soft tissues. Breast RDD is exceedingly rare. It may be clinically and radiographically similar to neoplastic and non-neoplastic diseases. We report a case of breast RDD in a 68-year-old female patient and describe the clinical imaging and pathological features of the patient. The management of extranodal RDD is individualized, and there are no standardized guidelines for treatment. We highlight the importance of considering the diagnosis of extranodal breast RDD, and suggest that surgical resection is an effective way to treat this disease, particularly for single-focal breast lesions with RDD.https://www.frontiersin.org/articles/10.3389/fonc.2025.1474931/fullbreastRosai-Dorfman diseaseextranodal RDDpathological diagnosissurgical treatment |
| spellingShingle | Yuan Lin Ya-Wen Wang Li-Xin Li Zhong-Qi Qiao Zhong-Qi Qiao Xu Chen Yan-Duo Chen Can Liu Kai Zhang A case report of breast Rosai-Dorfman disease and a literature review Frontiers in Oncology breast Rosai-Dorfman disease extranodal RDD pathological diagnosis surgical treatment |
| title | A case report of breast Rosai-Dorfman disease and a literature review |
| title_full | A case report of breast Rosai-Dorfman disease and a literature review |
| title_fullStr | A case report of breast Rosai-Dorfman disease and a literature review |
| title_full_unstemmed | A case report of breast Rosai-Dorfman disease and a literature review |
| title_short | A case report of breast Rosai-Dorfman disease and a literature review |
| title_sort | case report of breast rosai dorfman disease and a literature review |
| topic | breast Rosai-Dorfman disease extranodal RDD pathological diagnosis surgical treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1474931/full |
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