BK Virus in Kidney Transplant Recipients: The Influence of Immunosuppression
The incidence of BK virus infection in kidney transplant recipients has increased over recent decades, coincident with the use of more potent immunosuppression. More importantly, posttransplant BK virus replication has emerged as an important cause of graft damage and subsequent graft loss. Immunosu...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2011/750836 |
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| _version_ | 1849398277119672320 |
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| author | Katherine A. Barraclough Nicole M. Isbel Christine E. Staatz David W. Johnson |
| author_facet | Katherine A. Barraclough Nicole M. Isbel Christine E. Staatz David W. Johnson |
| author_sort | Katherine A. Barraclough |
| collection | DOAJ |
| description | The incidence of BK virus infection in kidney transplant recipients has increased over recent decades, coincident with the use of more potent immunosuppression. More importantly, posttransplant BK virus replication has emerged as an important cause of graft damage and subsequent graft loss. Immunosuppression has been accepted as a major risk for BK virus replication. However, the specific contribution of individual immunosuppressive medications to this risk has not been well established. The purpose of this paper is to provide an overview of the recent literature on the influence of the various immunosuppressant drugs and drug combinations on posttransplant BK virus replication. Evidence supporting the various immunosuppression reduction strategies utilised in the management of BK virus will also be briefly discussed. |
| format | Article |
| id | doaj-art-9e315e8a72294ff1aeeed089dd3f6eb5 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-9e315e8a72294ff1aeeed089dd3f6eb52025-08-20T03:38:39ZengWileyJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/750836750836BK Virus in Kidney Transplant Recipients: The Influence of ImmunosuppressionKatherine A. Barraclough0Nicole M. Isbel1Christine E. Staatz2David W. Johnson3Department of Nephrology, University of Queensland at the Princess Alexandra Hospital, Brisbane, QLD 4102, AustraliaDepartment of Nephrology, University of Queensland at the Princess Alexandra Hospital, Brisbane, QLD 4102, AustraliaSchool of Pharmacy, University of Queensland, St Lucia, Brisbane, QLD 4072, AustraliaDepartment of Nephrology, University of Queensland at the Princess Alexandra Hospital, Brisbane, QLD 4102, AustraliaThe incidence of BK virus infection in kidney transplant recipients has increased over recent decades, coincident with the use of more potent immunosuppression. More importantly, posttransplant BK virus replication has emerged as an important cause of graft damage and subsequent graft loss. Immunosuppression has been accepted as a major risk for BK virus replication. However, the specific contribution of individual immunosuppressive medications to this risk has not been well established. The purpose of this paper is to provide an overview of the recent literature on the influence of the various immunosuppressant drugs and drug combinations on posttransplant BK virus replication. Evidence supporting the various immunosuppression reduction strategies utilised in the management of BK virus will also be briefly discussed.http://dx.doi.org/10.1155/2011/750836 |
| spellingShingle | Katherine A. Barraclough Nicole M. Isbel Christine E. Staatz David W. Johnson BK Virus in Kidney Transplant Recipients: The Influence of Immunosuppression Journal of Transplantation |
| title | BK Virus in Kidney Transplant Recipients: The Influence of Immunosuppression |
| title_full | BK Virus in Kidney Transplant Recipients: The Influence of Immunosuppression |
| title_fullStr | BK Virus in Kidney Transplant Recipients: The Influence of Immunosuppression |
| title_full_unstemmed | BK Virus in Kidney Transplant Recipients: The Influence of Immunosuppression |
| title_short | BK Virus in Kidney Transplant Recipients: The Influence of Immunosuppression |
| title_sort | bk virus in kidney transplant recipients the influence of immunosuppression |
| url | http://dx.doi.org/10.1155/2011/750836 |
| work_keys_str_mv | AT katherineabarraclough bkvirusinkidneytransplantrecipientstheinfluenceofimmunosuppression AT nicolemisbel bkvirusinkidneytransplantrecipientstheinfluenceofimmunosuppression AT christineestaatz bkvirusinkidneytransplantrecipientstheinfluenceofimmunosuppression AT davidwjohnson bkvirusinkidneytransplantrecipientstheinfluenceofimmunosuppression |