Recent updates of centromere proteins in hepatocellular carcinoma: a review
Abstract Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide, with approximately 800,000 deaths worldwide each year. Owing to the atypical early symptoms and characteristics of HCC, over 80% of HCC patients cannot receive curative treatment. The treatment of...
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BMC
2025-02-01
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| Online Access: | https://doi.org/10.1186/s13027-024-00630-2 |
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| author | Zhongyuan Yang Wenjiao Chen Yunhui Liu Yuxin Niu |
| author_facet | Zhongyuan Yang Wenjiao Chen Yunhui Liu Yuxin Niu |
| author_sort | Zhongyuan Yang |
| collection | DOAJ |
| description | Abstract Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide, with approximately 800,000 deaths worldwide each year. Owing to the atypical early symptoms and characteristics of HCC, over 80% of HCC patients cannot receive curative treatment. The treatment of HCC is facing a bottleneck, and new treatment methods are urgently needed. Since the pathogenesis of HCC is not yet clear, identifying the molecular mechanisms and therapeutic targets related to it is crucial. Centromeres are considered special deoxyribonucleic acid (DNA) sequences with highly repetitive sequences that are physically connected to the spindle during cell division, ensuring equal division of genetic material between daughter cells. The numerous proteins that aggregate on this sequence during cell division are called centromere proteins (CENPs). Currently, numerous studies have shown that CENPs are abnormally expressed in tumor cells and are associated with patient prognosis. The abnormal expression of CENPs is a key cause of chromosomal instability. Furthermore, chromosomal instability is a common characteristic of the majority of tumors. Chromosomal instability can lead to uncontrolled and sustained division and proliferation of malignant tumors. Therapeutic plans targeting CENPs play important roles in the treatment of HCC. For example, small ribonucleic acid (RNA) can silence CENP expression and prevent the occurrence and development of liver cancer. In recent years, studies of HCC-targeting CENPs have gradually increased but are still relatively novel, requiring further systematic elaboration. In this review, we provide a detailed introduction to the characteristics of CENPs and discuss their roles in HCC. In addition, we discuss their application prospects in future clinical practice. |
| format | Article |
| id | doaj-art-9e2dcfeca61f4f11b9a87b054976fd62 |
| institution | Kabale University |
| issn | 1750-9378 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | Infectious Agents and Cancer |
| spelling | doaj-art-9e2dcfeca61f4f11b9a87b054976fd622025-02-09T12:13:10ZengBMCInfectious Agents and Cancer1750-93782025-02-0120111210.1186/s13027-024-00630-2Recent updates of centromere proteins in hepatocellular carcinoma: a reviewZhongyuan Yang0Wenjiao Chen1Yunhui Liu2Yuxin Niu3Department of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and TechnologyDepartment of Dermatology, Wuhan Hankou HospitalDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and TechnologyDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and TechnologyAbstract Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide, with approximately 800,000 deaths worldwide each year. Owing to the atypical early symptoms and characteristics of HCC, over 80% of HCC patients cannot receive curative treatment. The treatment of HCC is facing a bottleneck, and new treatment methods are urgently needed. Since the pathogenesis of HCC is not yet clear, identifying the molecular mechanisms and therapeutic targets related to it is crucial. Centromeres are considered special deoxyribonucleic acid (DNA) sequences with highly repetitive sequences that are physically connected to the spindle during cell division, ensuring equal division of genetic material between daughter cells. The numerous proteins that aggregate on this sequence during cell division are called centromere proteins (CENPs). Currently, numerous studies have shown that CENPs are abnormally expressed in tumor cells and are associated with patient prognosis. The abnormal expression of CENPs is a key cause of chromosomal instability. Furthermore, chromosomal instability is a common characteristic of the majority of tumors. Chromosomal instability can lead to uncontrolled and sustained division and proliferation of malignant tumors. Therapeutic plans targeting CENPs play important roles in the treatment of HCC. For example, small ribonucleic acid (RNA) can silence CENP expression and prevent the occurrence and development of liver cancer. In recent years, studies of HCC-targeting CENPs have gradually increased but are still relatively novel, requiring further systematic elaboration. In this review, we provide a detailed introduction to the characteristics of CENPs and discuss their roles in HCC. In addition, we discuss their application prospects in future clinical practice.https://doi.org/10.1186/s13027-024-00630-2Hepatocellular carcinomaCentromere proteinChromosomal instabilityTherapeutic target |
| spellingShingle | Zhongyuan Yang Wenjiao Chen Yunhui Liu Yuxin Niu Recent updates of centromere proteins in hepatocellular carcinoma: a review Infectious Agents and Cancer Hepatocellular carcinoma Centromere protein Chromosomal instability Therapeutic target |
| title | Recent updates of centromere proteins in hepatocellular carcinoma: a review |
| title_full | Recent updates of centromere proteins in hepatocellular carcinoma: a review |
| title_fullStr | Recent updates of centromere proteins in hepatocellular carcinoma: a review |
| title_full_unstemmed | Recent updates of centromere proteins in hepatocellular carcinoma: a review |
| title_short | Recent updates of centromere proteins in hepatocellular carcinoma: a review |
| title_sort | recent updates of centromere proteins in hepatocellular carcinoma a review |
| topic | Hepatocellular carcinoma Centromere protein Chromosomal instability Therapeutic target |
| url | https://doi.org/10.1186/s13027-024-00630-2 |
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