Dynamic Heart Rate Variability Vector and Premature Ventricular Contractions Patterns in Adult Hemodialysis Patients: A 48 h Risk Exploration
Chronic kidney disease (CKD) is a progressive pathology characterized by gradual function loss. It is accompanied by complications including cardiovascular disorders. This study involves 4-h electrocardiographic records from the Telemetric and Holter ECG Warehouse (THEW) project database to analyze...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/15/9/5122 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849322484355039232 |
|---|---|
| author | Gabriel Vega-Martínez Francisco José Ramos-Becerril Josefina Gutiérrez-Martínez Arturo Vera-Hernández Carlos Alvarado-Serrano Lorenzo Leija-Salas |
| author_facet | Gabriel Vega-Martínez Francisco José Ramos-Becerril Josefina Gutiérrez-Martínez Arturo Vera-Hernández Carlos Alvarado-Serrano Lorenzo Leija-Salas |
| author_sort | Gabriel Vega-Martínez |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is a progressive pathology characterized by gradual function loss. It is accompanied by complications including cardiovascular disorders. This study involves 4-h electrocardiographic records from the Telemetric and Holter ECG Warehouse (THEW) project database to analyze the dynamics in heart rate variability (HRV) indices of 51 patients with CKD. It proposes three algorithms to process long-term electrocardiography records: QRS complex and R-wave detection, premature ventricular contraction (PVC) identification, and tachograms. PVCs were analyzed with the consideration of the changes occurring before, during, and after hemodialysis, especially during the interdialytic period. The hour with the highest PVCs occurrence was identified and used to assess HRV fluctuations and segmented into 5 min blocks with a 0.77 min overlap, yielding a dynamic HRV vector, one for each of seven HRV indices selected to evaluate autonomic nervous system balance. R-wave and PVC identification resulted in 97.53% and 85.83% positive predictive values, respectively. PVCs’ prevalence and HRV changes’ relationship in 48 h records could relate to cardiovascular risk. The stratification of hemodialysis patients into three distinct PVC patterns (<i>p</i> < 0.001) identified two clinically significant high-risk subgroups: Class 1, indicative of electrical instability, and Class 3, of advanced autonomic dysfunction, demonstrating divergent arrhythmogenic mechanisms with direct implications for risk stratification. |
| format | Article |
| id | doaj-art-9e2d7c9f48974a85861dbf5718525b8f |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-9e2d7c9f48974a85861dbf5718525b8f2025-08-20T03:49:22ZengMDPI AGApplied Sciences2076-34172025-05-01159512210.3390/app15095122Dynamic Heart Rate Variability Vector and Premature Ventricular Contractions Patterns in Adult Hemodialysis Patients: A 48 h Risk ExplorationGabriel Vega-Martínez0Francisco José Ramos-Becerril1Josefina Gutiérrez-Martínez2Arturo Vera-Hernández3Carlos Alvarado-Serrano4Lorenzo Leija-Salas5Centro de Investigación y de Estudios Avanzados del IPN, Av. Instituto Politécnico Nacional 2508, San Pedro Zacatenco, G.A.M., Mexico City 07360, MexicoInstituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Calzada México-Xochimilco 289, Arenal de Guadalupe, Mexico City 14389, MexicoInstituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Calzada México-Xochimilco 289, Arenal de Guadalupe, Mexico City 14389, MexicoCentro de Investigación y de Estudios Avanzados del IPN, Av. Instituto Politécnico Nacional 2508, San Pedro Zacatenco, G.A.M., Mexico City 07360, MexicoCentro de Investigación y de Estudios Avanzados del IPN, Av. Instituto Politécnico Nacional 2508, San Pedro Zacatenco, G.A.M., Mexico City 07360, MexicoCentro de Investigación y de Estudios Avanzados del IPN, Av. Instituto Politécnico Nacional 2508, San Pedro Zacatenco, G.A.M., Mexico City 07360, MexicoChronic kidney disease (CKD) is a progressive pathology characterized by gradual function loss. It is accompanied by complications including cardiovascular disorders. This study involves 4-h electrocardiographic records from the Telemetric and Holter ECG Warehouse (THEW) project database to analyze the dynamics in heart rate variability (HRV) indices of 51 patients with CKD. It proposes three algorithms to process long-term electrocardiography records: QRS complex and R-wave detection, premature ventricular contraction (PVC) identification, and tachograms. PVCs were analyzed with the consideration of the changes occurring before, during, and after hemodialysis, especially during the interdialytic period. The hour with the highest PVCs occurrence was identified and used to assess HRV fluctuations and segmented into 5 min blocks with a 0.77 min overlap, yielding a dynamic HRV vector, one for each of seven HRV indices selected to evaluate autonomic nervous system balance. R-wave and PVC identification resulted in 97.53% and 85.83% positive predictive values, respectively. PVCs’ prevalence and HRV changes’ relationship in 48 h records could relate to cardiovascular risk. The stratification of hemodialysis patients into three distinct PVC patterns (<i>p</i> < 0.001) identified two clinically significant high-risk subgroups: Class 1, indicative of electrical instability, and Class 3, of advanced autonomic dysfunction, demonstrating divergent arrhythmogenic mechanisms with direct implications for risk stratification.https://www.mdpi.com/2076-3417/15/9/5122autonomic nervous system balancechronic kidney diseasedynamic heart rate variabilityinterdialytic periodpremature ventricular contractions patterns |
| spellingShingle | Gabriel Vega-Martínez Francisco José Ramos-Becerril Josefina Gutiérrez-Martínez Arturo Vera-Hernández Carlos Alvarado-Serrano Lorenzo Leija-Salas Dynamic Heart Rate Variability Vector and Premature Ventricular Contractions Patterns in Adult Hemodialysis Patients: A 48 h Risk Exploration Applied Sciences autonomic nervous system balance chronic kidney disease dynamic heart rate variability interdialytic period premature ventricular contractions patterns |
| title | Dynamic Heart Rate Variability Vector and Premature Ventricular Contractions Patterns in Adult Hemodialysis Patients: A 48 h Risk Exploration |
| title_full | Dynamic Heart Rate Variability Vector and Premature Ventricular Contractions Patterns in Adult Hemodialysis Patients: A 48 h Risk Exploration |
| title_fullStr | Dynamic Heart Rate Variability Vector and Premature Ventricular Contractions Patterns in Adult Hemodialysis Patients: A 48 h Risk Exploration |
| title_full_unstemmed | Dynamic Heart Rate Variability Vector and Premature Ventricular Contractions Patterns in Adult Hemodialysis Patients: A 48 h Risk Exploration |
| title_short | Dynamic Heart Rate Variability Vector and Premature Ventricular Contractions Patterns in Adult Hemodialysis Patients: A 48 h Risk Exploration |
| title_sort | dynamic heart rate variability vector and premature ventricular contractions patterns in adult hemodialysis patients a 48 h risk exploration |
| topic | autonomic nervous system balance chronic kidney disease dynamic heart rate variability interdialytic period premature ventricular contractions patterns |
| url | https://www.mdpi.com/2076-3417/15/9/5122 |
| work_keys_str_mv | AT gabrielvegamartinez dynamicheartratevariabilityvectorandprematureventricularcontractionspatternsinadulthemodialysispatientsa48hriskexploration AT franciscojoseramosbecerril dynamicheartratevariabilityvectorandprematureventricularcontractionspatternsinadulthemodialysispatientsa48hriskexploration AT josefinagutierrezmartinez dynamicheartratevariabilityvectorandprematureventricularcontractionspatternsinadulthemodialysispatientsa48hriskexploration AT arturoverahernandez dynamicheartratevariabilityvectorandprematureventricularcontractionspatternsinadulthemodialysispatientsa48hriskexploration AT carlosalvaradoserrano dynamicheartratevariabilityvectorandprematureventricularcontractionspatternsinadulthemodialysispatientsa48hriskexploration AT lorenzoleijasalas dynamicheartratevariabilityvectorandprematureventricularcontractionspatternsinadulthemodialysispatientsa48hriskexploration |