Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure

Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure

Background. Endothelial function is impaired in chronic heart failure (CHF). Statins upregulate endothelial NO synthase (eNOS) and improve endothelial function. Recent studies demonstrated that HDL stimulates NO production due to eNOS phosphorylation at Ser1177, dephosphorylation at Thr495, and dimi...

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Main Authors: Ephraim B. Winzer, Pauline Gaida, Robert Höllriegel, Tina Fischer, Axel Linke, Gerhard Schuler, Volker Adams, Sandra Erbs
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Cardiology Research and Practice
Online Access:http://dx.doi.org/10.1155/2016/4826102
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