ALTERATIONS IN CATALASE, SUPEROXIDE DISMUTASE, GLUTATHIONE PEROXIDASE AND MALONDIALDEHYDE LEVELS IN SERUM AND LIVER TISSUE UNDER STRESS CONDITIONS
Objective: Chronic stress is a factor that affects organs/tissues and disrupts homeostasis. This condition can lead to increased oxidative stress, which damages cellular components. Antioxidants attempt to prevent this damage by neutralizing free radicals. Our study aimed to investigate the effect o...
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Istanbul University Press
2024-03-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/70B70653581841858CD51EA647DB3761 |
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| author | Mehmet Deniz Yener Tuncay Çolak Özgür Doğa Özsoy Fatma Ceyla Eraldemir |
| author_facet | Mehmet Deniz Yener Tuncay Çolak Özgür Doğa Özsoy Fatma Ceyla Eraldemir |
| author_sort | Mehmet Deniz Yener |
| collection | DOAJ |
| description | Objective: Chronic stress is a factor that affects organs/tissues and disrupts homeostasis. This condition can lead to increased oxidative stress, which damages cellular components. Antioxidants attempt to prevent this damage by neutralizing free radicals. Our study aimed to investigate the effect of chronic mild stress on the levels of Catalase (CAT), Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and Malondialdehyde (MDA) in serum and liver tissue. Material and Method: In our study, 16 Wistar albino rats were divided into control and experimental groups. The chronic unpredictable mild stress (CUMS) model protocol was employed. The levels of CAT, SOD, GPx, and MDA in serum and liver tissue were measured using the Enzyme-Linked Immunosorbent Assay method. Result: Upon comparison of serum CAT, SOD, GPx, and MDA levels, no statistically significant difference was observed between the control and stress groups (p>0.05). However, when comparing CAT, SOD, GPx, and MDA levels in the liver tissue, a significant increase in the levels of antioxidant enzymes was noted in the stress group (p<0.05). Conclusion: Under chronic stress, liver tissue's antioxidant levels appear to increase. We believe our study may contribute to understanding the connection between stress, free radicals, and antioxidants. |
| format | Article |
| id | doaj-art-9e2345bd94cb4ba689aca91dae4d0751 |
| institution | DOAJ |
| issn | 1305-6441 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-9e2345bd94cb4ba689aca91dae4d07512025-08-20T02:58:39ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412024-03-0187214515210.26650/IUITFD.1387837123456ALTERATIONS IN CATALASE, SUPEROXIDE DISMUTASE, GLUTATHIONE PEROXIDASE AND MALONDIALDEHYDE LEVELS IN SERUM AND LIVER TISSUE UNDER STRESS CONDITIONSMehmet Deniz Yener0https://orcid.org/0000-0002-4379-5793Tuncay Çolak1https://orcid.org/0000-0002-9483-3243Özgür Doğa Özsoy2https://orcid.org/0000-0002-6710-538XFatma Ceyla Eraldemir3https://orcid.org/0000-0001-9410-8554Kocaeli Üniversitesi, Kocaeli, TürkiyeKocaeli Üniversitesi, Kocaeli, TürkiyeKocaeli Üniversitesi, Kocaeli, TürkiyeKocaeli Üniversitesi, Kocaeli, TürkiyeObjective: Chronic stress is a factor that affects organs/tissues and disrupts homeostasis. This condition can lead to increased oxidative stress, which damages cellular components. Antioxidants attempt to prevent this damage by neutralizing free radicals. Our study aimed to investigate the effect of chronic mild stress on the levels of Catalase (CAT), Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and Malondialdehyde (MDA) in serum and liver tissue. Material and Method: In our study, 16 Wistar albino rats were divided into control and experimental groups. The chronic unpredictable mild stress (CUMS) model protocol was employed. The levels of CAT, SOD, GPx, and MDA in serum and liver tissue were measured using the Enzyme-Linked Immunosorbent Assay method. Result: Upon comparison of serum CAT, SOD, GPx, and MDA levels, no statistically significant difference was observed between the control and stress groups (p>0.05). However, when comparing CAT, SOD, GPx, and MDA levels in the liver tissue, a significant increase in the levels of antioxidant enzymes was noted in the stress group (p<0.05). Conclusion: Under chronic stress, liver tissue's antioxidant levels appear to increase. We believe our study may contribute to understanding the connection between stress, free radicals, and antioxidants.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/70B70653581841858CD51EA647DB3761antioxidantchronic stressoxidative stress |
| spellingShingle | Mehmet Deniz Yener Tuncay Çolak Özgür Doğa Özsoy Fatma Ceyla Eraldemir ALTERATIONS IN CATALASE, SUPEROXIDE DISMUTASE, GLUTATHIONE PEROXIDASE AND MALONDIALDEHYDE LEVELS IN SERUM AND LIVER TISSUE UNDER STRESS CONDITIONS İstanbul Tıp Fakültesi Dergisi antioxidant chronic stress oxidative stress |
| title | ALTERATIONS IN CATALASE, SUPEROXIDE DISMUTASE, GLUTATHIONE PEROXIDASE AND MALONDIALDEHYDE LEVELS IN SERUM AND LIVER TISSUE UNDER STRESS CONDITIONS |
| title_full | ALTERATIONS IN CATALASE, SUPEROXIDE DISMUTASE, GLUTATHIONE PEROXIDASE AND MALONDIALDEHYDE LEVELS IN SERUM AND LIVER TISSUE UNDER STRESS CONDITIONS |
| title_fullStr | ALTERATIONS IN CATALASE, SUPEROXIDE DISMUTASE, GLUTATHIONE PEROXIDASE AND MALONDIALDEHYDE LEVELS IN SERUM AND LIVER TISSUE UNDER STRESS CONDITIONS |
| title_full_unstemmed | ALTERATIONS IN CATALASE, SUPEROXIDE DISMUTASE, GLUTATHIONE PEROXIDASE AND MALONDIALDEHYDE LEVELS IN SERUM AND LIVER TISSUE UNDER STRESS CONDITIONS |
| title_short | ALTERATIONS IN CATALASE, SUPEROXIDE DISMUTASE, GLUTATHIONE PEROXIDASE AND MALONDIALDEHYDE LEVELS IN SERUM AND LIVER TISSUE UNDER STRESS CONDITIONS |
| title_sort | alterations in catalase superoxide dismutase glutathione peroxidase and malondialdehyde levels in serum and liver tissue under stress conditions |
| topic | antioxidant chronic stress oxidative stress |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/70B70653581841858CD51EA647DB3761 |
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