A sex-sensitive LC-MS/MS method with isotopic internal standard for prazosin bioequivalence: bridging precision medicine and generic drug policy in China

A sex-sensitive LC-MS/MS method with isotopic internal standard for prazosin bioequivalence: bridging precision medicine and generic drug policy in China

ObjectiveTo develop a rapid, sensitive, and high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for prazosin quantification in human plasma, validate its application in bioequivalence studies, and investigate sex-specific pharmacokinetic differences in a Chinese populati...

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Bibliographic Details
Main Authors: Hui Chen, Junping Guo, Zhenyu Zhu, Xiaomei Huang, Jincai Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
prazosin
prazosin-d8
LC-MS/MS
pharmacokinetics
bioequivalence
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1592731/full
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