Thyroidectomy in children and adolescents: distinguishing benign from malignant thyroid nodules
Objectives: The research aimed to analyze the clinical, epidemiological, laboratory, imaging, and pathological characteristics of pediatric patients who underwent surgery for thyroid nodules, distinguishing and comparing malignant and benign conditions. Methodology: A retrospective and descriptive a...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Jornal de Pediatria |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0021755725001160 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849228457307799552 |
|---|---|
| author | Mário Sérgio Rocha Macedo Jônatas Catunda de Freitas Débora Cabral Coutinho Carina Marques Barroso Sandra Regina Geroldo Rhuce Pedrosa Carvalho Letícia Siqueira Monte Alverne Tamyres Ferreira Campos Lívia Rolim Fernades Macedo José Huygens Parente Garcia Wellington Alves Filho |
| author_facet | Mário Sérgio Rocha Macedo Jônatas Catunda de Freitas Débora Cabral Coutinho Carina Marques Barroso Sandra Regina Geroldo Rhuce Pedrosa Carvalho Letícia Siqueira Monte Alverne Tamyres Ferreira Campos Lívia Rolim Fernades Macedo José Huygens Parente Garcia Wellington Alves Filho |
| author_sort | Mário Sérgio Rocha Macedo |
| collection | DOAJ |
| description | Objectives: The research aimed to analyze the clinical, epidemiological, laboratory, imaging, and pathological characteristics of pediatric patients who underwent surgery for thyroid nodules, distinguishing and comparing malignant and benign conditions. Methodology: A retrospective and descriptive analysis was conducted on patients aged 0–18 years who underwent thyroidectomy. The following variables were evaluated: gender, previous and current pathological history, laboratory thyroid hormone levels, ultrasonography, cytology, and histopathological findings. Results: A total of 91 children underwent thyroidectomy from January 2013 to May 2023. The average age was 13 years, and 68 patients were female. Ultrasonography evaluation revealed that 62 children had unimodular disease. Histopathology reports showed benign tumors in 54 patients and malignant tumors in 37. The factors associated with a higher incidence of cancer in univariate analysis were age < 10 years (p = 0.025), the presence of nodules on ultrasound with microcalcification (p < 0.001), and hypoechogenic nodules (p = 0.007). On multivariate analysis, only age under 10 years (OR = 5.69; p = 0.028) and the presence of microcalcifications (OR = 28.44 and p = 0.002) were significantly associated with malignancy. Conclusion: The medical community is becoming increasingly aware of the differences in the clinical, epidemiological, pathological, and molecular presentations of benign and malignant thyroid diseases, highlighting the need for further training in this area. |
| format | Article |
| id | doaj-art-9e1ed0c47c464019a6815d84609e03e9 |
| institution | Kabale University |
| issn | 0021-7557 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj-art-9e1ed0c47c464019a6815d84609e03e92025-08-23T04:47:20ZengElsevierJornal de Pediatria0021-75572025-09-01101510142610.1016/j.jped.2025.101426Thyroidectomy in children and adolescents: distinguishing benign from malignant thyroid nodulesMário Sérgio Rocha Macedo0Jônatas Catunda de Freitas1Débora Cabral Coutinho2Carina Marques Barroso3Sandra Regina Geroldo4Rhuce Pedrosa Carvalho5Letícia Siqueira Monte Alverne6Tamyres Ferreira Campos7Lívia Rolim Fernades Macedo8José Huygens Parente Garcia9Wellington Alves Filho10Hospital Infantil Albert Sabin, Fortaleza, CE, Brazil; Universidade Federal do Ceará, Departamento de Cirurgia, Fortaleza, CE, Brazil; Corresponding author.Unicristhus, Fortaleza, CE, BrazilHospital Infantil Albert Sabin, Fortaleza, CE, BrazilHospital Infantil Albert Sabin, Fortaleza, CE, BrazilHospital Infantil Albert Sabin, Fortaleza, CE, BrazilHospital Infantil Albert Sabin, Fortaleza, CE, BrazilUnicristhus, Fortaleza, CE, BrazilUnicristhus, Fortaleza, CE, BrazilUnicristhus, Fortaleza, CE, BrazilUniversidade Federal do Ceará, Departamento de Cirurgia, Fortaleza, CE, BrazilUniversidade Federal do Ceará, Departamento de Cirurgia, Fortaleza, CE, BrazilObjectives: The research aimed to analyze the clinical, epidemiological, laboratory, imaging, and pathological characteristics of pediatric patients who underwent surgery for thyroid nodules, distinguishing and comparing malignant and benign conditions. Methodology: A retrospective and descriptive analysis was conducted on patients aged 0–18 years who underwent thyroidectomy. The following variables were evaluated: gender, previous and current pathological history, laboratory thyroid hormone levels, ultrasonography, cytology, and histopathological findings. Results: A total of 91 children underwent thyroidectomy from January 2013 to May 2023. The average age was 13 years, and 68 patients were female. Ultrasonography evaluation revealed that 62 children had unimodular disease. Histopathology reports showed benign tumors in 54 patients and malignant tumors in 37. The factors associated with a higher incidence of cancer in univariate analysis were age < 10 years (p = 0.025), the presence of nodules on ultrasound with microcalcification (p < 0.001), and hypoechogenic nodules (p = 0.007). On multivariate analysis, only age under 10 years (OR = 5.69; p = 0.028) and the presence of microcalcifications (OR = 28.44 and p = 0.002) were significantly associated with malignancy. Conclusion: The medical community is becoming increasingly aware of the differences in the clinical, epidemiological, pathological, and molecular presentations of benign and malignant thyroid diseases, highlighting the need for further training in this area.http://www.sciencedirect.com/science/article/pii/S0021755725001160ThyroidectomyChildrenNodule |
| spellingShingle | Mário Sérgio Rocha Macedo Jônatas Catunda de Freitas Débora Cabral Coutinho Carina Marques Barroso Sandra Regina Geroldo Rhuce Pedrosa Carvalho Letícia Siqueira Monte Alverne Tamyres Ferreira Campos Lívia Rolim Fernades Macedo José Huygens Parente Garcia Wellington Alves Filho Thyroidectomy in children and adolescents: distinguishing benign from malignant thyroid nodules Jornal de Pediatria Thyroidectomy Children Nodule |
| title | Thyroidectomy in children and adolescents: distinguishing benign from malignant thyroid nodules |
| title_full | Thyroidectomy in children and adolescents: distinguishing benign from malignant thyroid nodules |
| title_fullStr | Thyroidectomy in children and adolescents: distinguishing benign from malignant thyroid nodules |
| title_full_unstemmed | Thyroidectomy in children and adolescents: distinguishing benign from malignant thyroid nodules |
| title_short | Thyroidectomy in children and adolescents: distinguishing benign from malignant thyroid nodules |
| title_sort | thyroidectomy in children and adolescents distinguishing benign from malignant thyroid nodules |
| topic | Thyroidectomy Children Nodule |
| url | http://www.sciencedirect.com/science/article/pii/S0021755725001160 |
| work_keys_str_mv | AT mariosergiorochamacedo thyroidectomyinchildrenandadolescentsdistinguishingbenignfrommalignantthyroidnodules AT jonatascatundadefreitas thyroidectomyinchildrenandadolescentsdistinguishingbenignfrommalignantthyroidnodules AT deboracabralcoutinho thyroidectomyinchildrenandadolescentsdistinguishingbenignfrommalignantthyroidnodules AT carinamarquesbarroso thyroidectomyinchildrenandadolescentsdistinguishingbenignfrommalignantthyroidnodules AT sandrareginageroldo thyroidectomyinchildrenandadolescentsdistinguishingbenignfrommalignantthyroidnodules AT rhucepedrosacarvalho thyroidectomyinchildrenandadolescentsdistinguishingbenignfrommalignantthyroidnodules AT leticiasiqueiramontealverne thyroidectomyinchildrenandadolescentsdistinguishingbenignfrommalignantthyroidnodules AT tamyresferreiracampos thyroidectomyinchildrenandadolescentsdistinguishingbenignfrommalignantthyroidnodules AT liviarolimfernadesmacedo thyroidectomyinchildrenandadolescentsdistinguishingbenignfrommalignantthyroidnodules AT josehuygensparentegarcia thyroidectomyinchildrenandadolescentsdistinguishingbenignfrommalignantthyroidnodules AT wellingtonalvesfilho thyroidectomyinchildrenandadolescentsdistinguishingbenignfrommalignantthyroidnodules |