Adverse Drug–Drug Interaction Between Phenobarbital and Fluconazole in Two Dogs

Adverse Drug–Drug Interaction Between Phenobarbital and Fluconazole in Two Dogs

ABSTRACT Phenobarbital (PB) is an antiseizure medication widely used in dogs that is metabolized by hepatic cytochrome P450 (CYP) enzymes. Fluconazole, a commonly prescribed antifungal medication, inhibits several CYP isoenzymes and can impair PB metabolism. Genetic polymorphisms such as the CYP2C41...

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Bibliographic Details
Main Authors: Maria Jaramillo, Alejandra Mondino, Michael Court, Melissa J. Lewis, Natasha J. Olby, Karen R. Muñana
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Journal of Veterinary Internal Medicine
Subjects:
antiseizure medication
canine
CYP2C41
cytochrome P450
epilepsy
hepatotoxicity
Online Access:https://doi.org/10.1111/jvim.70190
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