Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?
Arrhythmogenic cardiomyopathy (AC) is a clinical entity that has evolved conceptually over the past 30 years. Advances in cardiac imaging and the introduction of genetics into everyday practice have revealed that AC comprises multiple phenotypes that are dependent on genetic or acquired factors. In...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Radcliffe Medical Media
2020-02-01
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| Series: | European Cardiology Review |
| Online Access: | https://www.ecrjournal.com/articleindex/ecr.2019.05 |
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| _version_ | 1850110594609315840 |
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| author | Alexandros Protonotarios Perry M Elliott |
| author_facet | Alexandros Protonotarios Perry M Elliott |
| author_sort | Alexandros Protonotarios |
| collection | DOAJ |
| description | Arrhythmogenic cardiomyopathy (AC) is a clinical entity that has evolved conceptually over the past 30 years. Advances in cardiac imaging and the introduction of genetics into everyday practice have revealed that AC comprises multiple phenotypes that are dependent on genetic or acquired factors. In this study, the authors summarise the approach to the identification of the AC phenotype and its underlying causes. They believe that AC represents a paradigm for personalised medicine in cardiology and that better stratification of the disease will enhance the development of mechanism-based treatments. |
| format | Article |
| id | doaj-art-9e1b0ed11e47415abb4aff05f585f33b |
| institution | OA Journals |
| issn | 1758-3756 1758-3764 |
| language | English |
| publishDate | 2020-02-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | European Cardiology Review |
| spelling | doaj-art-9e1b0ed11e47415abb4aff05f585f33b2025-08-20T02:37:48ZengRadcliffe Medical MediaEuropean Cardiology Review1758-37561758-37642020-02-011510.15420/ecr.2019.05Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?Alexandros Protonotarios0Perry M Elliott1Institute of Cardiovascular Science, University College London, London, UK; Inherited Cardiovascular Disease Unit, Barts Heart Centre, London, UKInstitute of Cardiovascular Science, University College London, London, UK; Inherited Cardiovascular Disease Unit, Barts Heart Centre, London, UKArrhythmogenic cardiomyopathy (AC) is a clinical entity that has evolved conceptually over the past 30 years. Advances in cardiac imaging and the introduction of genetics into everyday practice have revealed that AC comprises multiple phenotypes that are dependent on genetic or acquired factors. In this study, the authors summarise the approach to the identification of the AC phenotype and its underlying causes. They believe that AC represents a paradigm for personalised medicine in cardiology and that better stratification of the disease will enhance the development of mechanism-based treatments.https://www.ecrjournal.com/articleindex/ecr.2019.05 |
| spellingShingle | Alexandros Protonotarios Perry M Elliott Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype? European Cardiology Review |
| title | Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype? |
| title_full | Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype? |
| title_fullStr | Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype? |
| title_full_unstemmed | Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype? |
| title_short | Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype? |
| title_sort | arrhythmogenic cardiomyopathy a disease or merely a phenotype |
| url | https://www.ecrjournal.com/articleindex/ecr.2019.05 |
| work_keys_str_mv | AT alexandrosprotonotarios arrhythmogeniccardiomyopathyadiseaseormerelyaphenotype AT perrymelliott arrhythmogeniccardiomyopathyadiseaseormerelyaphenotype |