Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?

Arrhythmogenic cardiomyopathy (AC) is a clinical entity that has evolved conceptually over the past 30 years. Advances in cardiac imaging and the introduction of genetics into everyday practice have revealed that AC comprises multiple phenotypes that are dependent on genetic or acquired factors. In...

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Bibliographic Details
Main Authors: Alexandros Protonotarios, Perry M Elliott
Format: Article
Language:English
Published: Radcliffe Medical Media 2020-02-01
Series:European Cardiology Review
Online Access:https://www.ecrjournal.com/articleindex/ecr.2019.05
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Summary:Arrhythmogenic cardiomyopathy (AC) is a clinical entity that has evolved conceptually over the past 30 years. Advances in cardiac imaging and the introduction of genetics into everyday practice have revealed that AC comprises multiple phenotypes that are dependent on genetic or acquired factors. In this study, the authors summarise the approach to the identification of the AC phenotype and its underlying causes. They believe that AC represents a paradigm for personalised medicine in cardiology and that better stratification of the disease will enhance the development of mechanism-based treatments.
ISSN:1758-3756
1758-3764