Thrombocytopenia in Liver Disease
Moderate thrombocytopenia is a frequent finding in cirrhosis of the liver and well tolerated in most instances. The pathophysiology of thrombocytopenia in liver disease has long been associated with the concept of hypersplenism, where portal hypertension was thought to cause pooling and sequestratio...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/617428 |
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| Summary: | Moderate thrombocytopenia
is a frequent finding in cirrhosis of the liver and well
tolerated in most instances. The pathophysiology of thrombocytopenia
in liver disease has long been associated with the concept
of hypersplenism, where portal hypertension was thought to cause
pooling and sequestration of all corpuscular elements of the blood,
predominantly thrombocytes in the enlarged spleen. The concept of
hypersplenism was never proven beyond any doubt but was widely
accepted for the lack of alternative explanations. |
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| ISSN: | 0835-7900 |