Clinical, Epidemiological, and Immunohematological Profile of Hemolytic Uremic Syndrome in Children Between 6 Months and 12 Years at a Tertiary Care Center in South India
Background: Hemolytic uremic syndrome (HUS) is a common cause of community acquired acute kidney injury (AKI) in childhood. Methodology: This descriptive study was conducted on 24 children from May 2019 to September 2020 at the Institute of Child Health and Hospital for Children, Chennai. Results: A...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_581_25 |
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| author | Vinushya Selvam H Syed Mohammed Lakshmi Velmurugan X Joshua Rajan |
| author_facet | Vinushya Selvam H Syed Mohammed Lakshmi Velmurugan X Joshua Rajan |
| author_sort | Vinushya Selvam |
| collection | DOAJ |
| description | Background:
Hemolytic uremic syndrome (HUS) is a common cause of community acquired acute kidney injury (AKI) in childhood.
Methodology:
This descriptive study was conducted on 24 children from May 2019 to September 2020 at the Institute of Child Health and Hospital for Children, Chennai.
Results:
Among the study population, 62.5% of children had atypical hemolytic uremic syndrome (HUS) and 37.5% had typical HUS. The prevalence of HUS was equal between girls and boys in the study population. The mortality rate was higher in girls compared to boys. The progression to chronic kidney disease (CKD) was also more in girls. Clinical findings that were statistically significant concerning the overall outcome of this study were hypertension, acidotic breathing, and encephalopathy. The mean hemoglobin level is 5.8 g/dL and the association of hemoglobin with outcome was not statistically significant. Mortality was high in extremes of ages.
Conclusion:
High lactate dehydrogenase (LDH) was associated with poor outcomes whereas normal C3 and early hematology resolution were associated with better outcomes. |
| format | Article |
| id | doaj-art-9e10b48d5b744fb79aa8e9aa054fa51e |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-9e10b48d5b744fb79aa8e9aa054fa51e2025-08-20T03:31:35ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-06-0117Suppl 2S1865S186710.4103/jpbs.jpbs_581_25Clinical, Epidemiological, and Immunohematological Profile of Hemolytic Uremic Syndrome in Children Between 6 Months and 12 Years at a Tertiary Care Center in South IndiaVinushya SelvamH Syed MohammedLakshmi VelmuruganX Joshua RajanBackground: Hemolytic uremic syndrome (HUS) is a common cause of community acquired acute kidney injury (AKI) in childhood. Methodology: This descriptive study was conducted on 24 children from May 2019 to September 2020 at the Institute of Child Health and Hospital for Children, Chennai. Results: Among the study population, 62.5% of children had atypical hemolytic uremic syndrome (HUS) and 37.5% had typical HUS. The prevalence of HUS was equal between girls and boys in the study population. The mortality rate was higher in girls compared to boys. The progression to chronic kidney disease (CKD) was also more in girls. Clinical findings that were statistically significant concerning the overall outcome of this study were hypertension, acidotic breathing, and encephalopathy. The mean hemoglobin level is 5.8 g/dL and the association of hemoglobin with outcome was not statistically significant. Mortality was high in extremes of ages. Conclusion: High lactate dehydrogenase (LDH) was associated with poor outcomes whereas normal C3 and early hematology resolution were associated with better outcomes.https://journals.lww.com/10.4103/jpbs.jpbs_581_25childrenhemolytic uremic syndromeimmunohematological |
| spellingShingle | Vinushya Selvam H Syed Mohammed Lakshmi Velmurugan X Joshua Rajan Clinical, Epidemiological, and Immunohematological Profile of Hemolytic Uremic Syndrome in Children Between 6 Months and 12 Years at a Tertiary Care Center in South India Journal of Pharmacy and Bioallied Sciences children hemolytic uremic syndrome immunohematological |
| title | Clinical, Epidemiological, and Immunohematological Profile of Hemolytic Uremic Syndrome in Children Between 6 Months and 12 Years at a Tertiary Care Center in South India |
| title_full | Clinical, Epidemiological, and Immunohematological Profile of Hemolytic Uremic Syndrome in Children Between 6 Months and 12 Years at a Tertiary Care Center in South India |
| title_fullStr | Clinical, Epidemiological, and Immunohematological Profile of Hemolytic Uremic Syndrome in Children Between 6 Months and 12 Years at a Tertiary Care Center in South India |
| title_full_unstemmed | Clinical, Epidemiological, and Immunohematological Profile of Hemolytic Uremic Syndrome in Children Between 6 Months and 12 Years at a Tertiary Care Center in South India |
| title_short | Clinical, Epidemiological, and Immunohematological Profile of Hemolytic Uremic Syndrome in Children Between 6 Months and 12 Years at a Tertiary Care Center in South India |
| title_sort | clinical epidemiological and immunohematological profile of hemolytic uremic syndrome in children between 6 months and 12 years at a tertiary care center in south india |
| topic | children hemolytic uremic syndrome immunohematological |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_581_25 |
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