Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms.
Retinal networks must adapt constantly to best present the ever changing visual world to the brain. Here we test the hypothesis that adaptation is a result of different mechanisms at several synaptic connections within the network. In a companion paper (Part I), we showed that adaptation in the phot...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004306&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850108104229781504 |
|---|---|
| author | Anton Nikolaev Lei Zheng Trevor J Wardill Cahir J O'Kane Gonzalo G de Polavieja Mikko Juusola |
| author_facet | Anton Nikolaev Lei Zheng Trevor J Wardill Cahir J O'Kane Gonzalo G de Polavieja Mikko Juusola |
| author_sort | Anton Nikolaev |
| collection | DOAJ |
| description | Retinal networks must adapt constantly to best present the ever changing visual world to the brain. Here we test the hypothesis that adaptation is a result of different mechanisms at several synaptic connections within the network. In a companion paper (Part I), we showed that adaptation in the photoreceptors (R1-R6) and large monopolar cells (LMC) of the Drosophila eye improves sensitivity to under-represented signals in seconds by enhancing both the amplitude and frequency distribution of LMCs' voltage responses to repeated naturalistic contrast series. In this paper, we show that such adaptation needs both the light-mediated conductance and feedback-mediated synaptic conductance. A faulty feedforward pathway in histamine receptor mutant flies speeds up the LMC output, mimicking extreme light adaptation. A faulty feedback pathway from L2 LMCs to photoreceptors slows down the LMC output, mimicking dark adaptation. These results underline the importance of network adaptation for efficient coding, and as a mechanism for selectively regulating the size and speed of signals in neurons. We suggest that concert action of many different mechanisms and neural connections are responsible for adaptation to visual stimuli. Further, our results demonstrate the need for detailed circuit reconstructions like that of the Drosophila lamina, to understand how networks process information. |
| format | Article |
| id | doaj-art-9dfd3c78ed61453eaa4f9bb811da3dc5 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-9dfd3c78ed61453eaa4f9bb811da3dc52025-08-20T02:38:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-01-0141e430610.1371/journal.pone.0004306Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms.Anton NikolaevLei ZhengTrevor J WardillCahir J O'KaneGonzalo G de PolaviejaMikko JuusolaRetinal networks must adapt constantly to best present the ever changing visual world to the brain. Here we test the hypothesis that adaptation is a result of different mechanisms at several synaptic connections within the network. In a companion paper (Part I), we showed that adaptation in the photoreceptors (R1-R6) and large monopolar cells (LMC) of the Drosophila eye improves sensitivity to under-represented signals in seconds by enhancing both the amplitude and frequency distribution of LMCs' voltage responses to repeated naturalistic contrast series. In this paper, we show that such adaptation needs both the light-mediated conductance and feedback-mediated synaptic conductance. A faulty feedforward pathway in histamine receptor mutant flies speeds up the LMC output, mimicking extreme light adaptation. A faulty feedback pathway from L2 LMCs to photoreceptors slows down the LMC output, mimicking dark adaptation. These results underline the importance of network adaptation for efficient coding, and as a mechanism for selectively regulating the size and speed of signals in neurons. We suggest that concert action of many different mechanisms and neural connections are responsible for adaptation to visual stimuli. Further, our results demonstrate the need for detailed circuit reconstructions like that of the Drosophila lamina, to understand how networks process information.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004306&type=printable |
| spellingShingle | Anton Nikolaev Lei Zheng Trevor J Wardill Cahir J O'Kane Gonzalo G de Polavieja Mikko Juusola Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms. PLoS ONE |
| title | Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms. |
| title_full | Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms. |
| title_fullStr | Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms. |
| title_full_unstemmed | Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms. |
| title_short | Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms. |
| title_sort | network adaptation improves temporal representation of naturalistic stimuli in drosophila eye ii mechanisms |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004306&type=printable |
| work_keys_str_mv | AT antonnikolaev networkadaptationimprovestemporalrepresentationofnaturalisticstimuliindrosophilaeyeiimechanisms AT leizheng networkadaptationimprovestemporalrepresentationofnaturalisticstimuliindrosophilaeyeiimechanisms AT trevorjwardill networkadaptationimprovestemporalrepresentationofnaturalisticstimuliindrosophilaeyeiimechanisms AT cahirjokane networkadaptationimprovestemporalrepresentationofnaturalisticstimuliindrosophilaeyeiimechanisms AT gonzalogdepolavieja networkadaptationimprovestemporalrepresentationofnaturalisticstimuliindrosophilaeyeiimechanisms AT mikkojuusola networkadaptationimprovestemporalrepresentationofnaturalisticstimuliindrosophilaeyeiimechanisms |