Expanding the Chemical Diversity of <i>Stemona parviflora</i>: Isolation and Characterization of New Parvistemoline-Type Alkaloids
A comprehensive phytochemical investigation of the whole plant of <i>Stemona parviflora</i> led to the isolation of 13 alkaloidal constituents, including five new alkaloids, parvistemonines B–F (<b>1</b>–<b>5</b>). The structures of these compounds were elucidated...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Chemistry |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-8549/7/1/6 |
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| Summary: | A comprehensive phytochemical investigation of the whole plant of <i>Stemona parviflora</i> led to the isolation of 13 alkaloidal constituents, including five new alkaloids, parvistemonines B–F (<b>1</b>–<b>5</b>). The structures of these compounds were elucidated through extensive analyses of 1D and 2D NMR spectra, DFT NMR calculation, and comparisons with data in the literature. Notably, compounds <b>1</b>–<b>4</b> represent new examples of the rare parvistemoline-type alkaloids, with compound <b>4</b> showcasing a unique rearranged skeleton. Additionally, parvistemonine F (<b>5</b>) was identified as a distinct alkaloid skeleton characterized by a <i>n</i>-butyl side chain. These findings significantly expand our understanding of the chemical diversity of parvistemoline-type alkaloids and provide clues for elucidating the biosynthetic pathways of these structurally unique parvistemoline alkaloids. |
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| ISSN: | 2624-8549 |