STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines

STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines

Abstract Background Obstructive sleep apnea (OSA) is frequently associated with increased incidence and mortality of pulmonary hypertension (PH). The immune response contributes to pulmonary artery remodeling and OSA-related diseases. The immunologic factors linked to OSA-induced PH are not well und...

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Bibliographic Details
Main Authors: Pan Jiang, Huai Huang, Zilong Liu, Guiling Xiang, Xiaodan Wu, Shengyu Hao, Shanqun Li
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Respiratory Research
Subjects:
Chronic intermittent hypoxia
Pulmonary hypertension
STAT6
Th2 immune response
Online Access:https://doi.org/10.1186/s12931-024-03062-z
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