Enhancing the Physical Properties of Calcium Silicate Cement Modified with Elastin-like Polypeptides and Bioactive Glass
Conventional calcium silicate cement (CSC) formulations often exhibit insufficient mechanical strength and low initial stability. This study aimed to develop an organic–inorganic hybrid biomaterial by incorporating an elastin-like polypeptide (ELP) (V125E8) and bioactive glass (BG) (63S) into CSC to...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4983/16/5/188 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850126354943574016 |
|---|---|
| author | Jiyoung Kwon Hyun-Jung Kim |
| author_facet | Jiyoung Kwon Hyun-Jung Kim |
| author_sort | Jiyoung Kwon |
| collection | DOAJ |
| description | Conventional calcium silicate cement (CSC) formulations often exhibit insufficient mechanical strength and low initial stability. This study aimed to develop an organic–inorganic hybrid biomaterial by incorporating an elastin-like polypeptide (ELP) (V125E8) and bioactive glass (BG) (63S) into CSC to improve its mechanical properties and wash-out resistance during the initial setting. Experimental groups included ProRoot MTA (Dentsply Sirona, USA) as a control (0BG), inorganic hybrids containing BG (2% or 5%; 2BG, 5BG), and organic–inorganic hybrids combining BG (2% or 5%; 2BG-L, 5BG-L) with a 10 wt% ELP solution. The compressive strength, microhardness, and wash-out resistance of the specimens were evaluated. The organic–inorganic hybrid groups (2BG-L and 5BG-L) exhibited significantly higher compressive strength and microhardness than the control (0BG) and inorganic-only groups (2BG and 5BG). Additionally, the incorporation of ELP markedly improved wash-out resistance, minimizing material disintegration during the initial setting in aqueous environments. The organic–inorganic hybrid groups (2BG-L and 5BG-L) exhibited significantly higher compressive strength and microhardness than the control (0BG) and inorganic-only groups (2BG and 5BG). Additionally, the incorporation of ELP markedly improved wash-out resistance, minimizing material disintegration during the initial setting in aqueous environments. |
| format | Article |
| id | doaj-art-9def00fa468f4266b387e75fc7cb0f22 |
| institution | OA Journals |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-9def00fa468f4266b387e75fc7cb0f222025-08-20T02:33:57ZengMDPI AGJournal of Functional Biomaterials2079-49832025-05-0116518810.3390/jfb16050188Enhancing the Physical Properties of Calcium Silicate Cement Modified with Elastin-like Polypeptides and Bioactive GlassJiyoung Kwon0Hyun-Jung Kim1Department of Conservative Dentistry, Kyung Hee University Dental Hospital, Seoul 02453, Republic of KoreaDepartment of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul 02453, Republic of KoreaConventional calcium silicate cement (CSC) formulations often exhibit insufficient mechanical strength and low initial stability. This study aimed to develop an organic–inorganic hybrid biomaterial by incorporating an elastin-like polypeptide (ELP) (V125E8) and bioactive glass (BG) (63S) into CSC to improve its mechanical properties and wash-out resistance during the initial setting. Experimental groups included ProRoot MTA (Dentsply Sirona, USA) as a control (0BG), inorganic hybrids containing BG (2% or 5%; 2BG, 5BG), and organic–inorganic hybrids combining BG (2% or 5%; 2BG-L, 5BG-L) with a 10 wt% ELP solution. The compressive strength, microhardness, and wash-out resistance of the specimens were evaluated. The organic–inorganic hybrid groups (2BG-L and 5BG-L) exhibited significantly higher compressive strength and microhardness than the control (0BG) and inorganic-only groups (2BG and 5BG). Additionally, the incorporation of ELP markedly improved wash-out resistance, minimizing material disintegration during the initial setting in aqueous environments. The organic–inorganic hybrid groups (2BG-L and 5BG-L) exhibited significantly higher compressive strength and microhardness than the control (0BG) and inorganic-only groups (2BG and 5BG). Additionally, the incorporation of ELP markedly improved wash-out resistance, minimizing material disintegration during the initial setting in aqueous environments.https://www.mdpi.com/2079-4983/16/5/188bioactive glasscalcium silicate cementselastin-like polypeptides |
| spellingShingle | Jiyoung Kwon Hyun-Jung Kim Enhancing the Physical Properties of Calcium Silicate Cement Modified with Elastin-like Polypeptides and Bioactive Glass Journal of Functional Biomaterials bioactive glass calcium silicate cements elastin-like polypeptides |
| title | Enhancing the Physical Properties of Calcium Silicate Cement Modified with Elastin-like Polypeptides and Bioactive Glass |
| title_full | Enhancing the Physical Properties of Calcium Silicate Cement Modified with Elastin-like Polypeptides and Bioactive Glass |
| title_fullStr | Enhancing the Physical Properties of Calcium Silicate Cement Modified with Elastin-like Polypeptides and Bioactive Glass |
| title_full_unstemmed | Enhancing the Physical Properties of Calcium Silicate Cement Modified with Elastin-like Polypeptides and Bioactive Glass |
| title_short | Enhancing the Physical Properties of Calcium Silicate Cement Modified with Elastin-like Polypeptides and Bioactive Glass |
| title_sort | enhancing the physical properties of calcium silicate cement modified with elastin like polypeptides and bioactive glass |
| topic | bioactive glass calcium silicate cements elastin-like polypeptides |
| url | https://www.mdpi.com/2079-4983/16/5/188 |
| work_keys_str_mv | AT jiyoungkwon enhancingthephysicalpropertiesofcalciumsilicatecementmodifiedwithelastinlikepolypeptidesandbioactiveglass AT hyunjungkim enhancingthephysicalpropertiesofcalciumsilicatecementmodifiedwithelastinlikepolypeptidesandbioactiveglass |