A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX
Abstract Background Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment. Case presentation A 56-year-old woman was diagnosed with...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Japan Surgical Society
2023-08-01
|
| Series: | Surgical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40792-023-01719-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849251072142475264 |
|---|---|
| author | Misato Araki Koshi Matsui Kohji Takagi Emi Kanaya Shinichi Sekine Shiho Nagasawa Toru Watanabe Takeshi Miwa Katsuhisa Hirano Takamichi Igarashi Haruyoshi Tanaka Kazuto Shibuya Isaya Hashimoto Shozo Hojo Isaku Yoshioka Tomoyuki Okumura Kenichi Hirabayashi Tsutomu Fujii |
| author_facet | Misato Araki Koshi Matsui Kohji Takagi Emi Kanaya Shinichi Sekine Shiho Nagasawa Toru Watanabe Takeshi Miwa Katsuhisa Hirano Takamichi Igarashi Haruyoshi Tanaka Kazuto Shibuya Isaya Hashimoto Shozo Hojo Isaku Yoshioka Tomoyuki Okumura Kenichi Hirabayashi Tsutomu Fujii |
| author_sort | Misato Araki |
| collection | DOAJ |
| description | Abstract Background Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment. Case presentation A 56-year-old woman was diagnosed with breast SCC with axillary, supraclavicular and internal thoracic lymph node metastases. She received neoadjuvant chemotherapy (NAC) with dose-dense doxorubicin and cyclophosphamide (AC) followed by dose-dense paclitaxel (PTX). This treatment resulted in a pathological complete response (pCR) after breast-conserving surgery. The patient was then treated with radiotherapy. She remained free of recurrence for three years postoperatively. Conclusions We report a rare case of breast SCC treated with preoperative dose-dense chemotherapy, resulting in pCR and allowing breast-conserving surgery. |
| format | Article |
| id | doaj-art-9def0097edab40688949bf2053ec37fe |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-9def0097edab40688949bf2053ec37fe2025-08-20T03:57:03ZengJapan Surgical SocietySurgical Case Reports2198-77932023-08-01911510.1186/s40792-023-01719-3A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTXMisato Araki0Koshi Matsui1Kohji Takagi2Emi Kanaya3Shinichi Sekine4Shiho Nagasawa5Toru Watanabe6Takeshi Miwa7Katsuhisa Hirano8Takamichi Igarashi9Haruyoshi Tanaka10Kazuto Shibuya11Isaya Hashimoto12Shozo Hojo13Isaku Yoshioka14Tomoyuki Okumura15Kenichi Hirabayashi16Tsutomu Fujii17Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Diagnostic Pathology, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Diagnostic Pathology, Faculty of Medicine, Academic Assembly, University of ToyamaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of ToyamaAbstract Background Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment. Case presentation A 56-year-old woman was diagnosed with breast SCC with axillary, supraclavicular and internal thoracic lymph node metastases. She received neoadjuvant chemotherapy (NAC) with dose-dense doxorubicin and cyclophosphamide (AC) followed by dose-dense paclitaxel (PTX). This treatment resulted in a pathological complete response (pCR) after breast-conserving surgery. The patient was then treated with radiotherapy. She remained free of recurrence for three years postoperatively. Conclusions We report a rare case of breast SCC treated with preoperative dose-dense chemotherapy, resulting in pCR and allowing breast-conserving surgery.https://doi.org/10.1186/s40792-023-01719-3Squamous cell carcinoma of the breastPathological complete responseNeoadjuvant chemotherapyBreast-conserving surgery |
| spellingShingle | Misato Araki Koshi Matsui Kohji Takagi Emi Kanaya Shinichi Sekine Shiho Nagasawa Toru Watanabe Takeshi Miwa Katsuhisa Hirano Takamichi Igarashi Haruyoshi Tanaka Kazuto Shibuya Isaya Hashimoto Shozo Hojo Isaku Yoshioka Tomoyuki Okumura Kenichi Hirabayashi Tsutomu Fujii A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX Surgical Case Reports Squamous cell carcinoma of the breast Pathological complete response Neoadjuvant chemotherapy Breast-conserving surgery |
| title | A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX |
| title_full | A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX |
| title_fullStr | A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX |
| title_full_unstemmed | A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX |
| title_short | A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX |
| title_sort | case of squamous cell carcinoma of the breast achieved a pathological complete response after dose dense ac dose dense ptx |
| topic | Squamous cell carcinoma of the breast Pathological complete response Neoadjuvant chemotherapy Breast-conserving surgery |
| url | https://doi.org/10.1186/s40792-023-01719-3 |
| work_keys_str_mv | AT misatoaraki acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT koshimatsui acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT kohjitakagi acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT emikanaya acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT shinichisekine acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT shihonagasawa acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT toruwatanabe acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT takeshimiwa acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT katsuhisahirano acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT takamichiigarashi acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT haruyoshitanaka acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT kazutoshibuya acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT isayahashimoto acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT shozohojo acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT isakuyoshioka acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT tomoyukiokumura acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT kenichihirabayashi acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT tsutomufujii acaseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT misatoaraki caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT koshimatsui caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT kohjitakagi caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT emikanaya caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT shinichisekine caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT shihonagasawa caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT toruwatanabe caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT takeshimiwa caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT katsuhisahirano caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT takamichiigarashi caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT haruyoshitanaka caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT kazutoshibuya caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT isayahashimoto caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT shozohojo caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT isakuyoshioka caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT tomoyukiokumura caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT kenichihirabayashi caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx AT tsutomufujii caseofsquamouscellcarcinomaofthebreastachievedapathologicalcompleteresponseafterdosedenseacdosedenseptx |