Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging

Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging

Abstract ATP-citrate lyase is a central integrator of cellular metabolism in the interface of protein, carbohydrate, and lipid metabolism. The physiological consequences as well as the molecular mechanisms orchestrating the response to long-term pharmacologically induced Acly inhibition are unknown....

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Main Authors: Alejandro Sola-García, María Ángeles Cáliz-Molina, Isabel Espadas, Michael Petr, Concepción Panadero-Morón, Daniel González-Morán, María Eugenia Martín-Vázquez, Álvaro Jesús Narbona-Pérez, Livia López-Noriega, Guillermo Martínez-Corrales, Raúl López-Fernández-Sobrino, Alejandro Castillo-Peña, Lina M. Carmona-Marin, Enrique Martínez-Force, Oscar Yanes, Maria Vinaixa, Daniel López-López, José Carlos Reyes, Joaquín Dopazo, Franz Martín, Benoit R. Gauthier, Morten Scheibye-Knudsen, Vivian Capilla-González, Alejandro Martín-Montalvo
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04625-4
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