Antimicrobial Hydroxyethyl-Cellulose-Based Composite Films with Zinc Oxide and Mesoporous Silica Loaded with Cinnamon Essential Oil
<b>Background</b>: Cellulose derivatives are gaining much attention in medical research due to their excellent properties such as biocompatibility, hydrophilicity, non-toxicity, sustainability, and low cost. Unfortunately, cellulose does not exhibit antimicrobial activity. However, deriv...
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2024-09-01
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| author | Ludmila Motelica Denisa Ficai Gabriela Petrisor Ovidiu-Cristian Oprea Roxana-Doina Trușcǎ Anton Ficai Ecaterina Andronescu Ariana Hudita Alina Maria Holban |
| author_facet | Ludmila Motelica Denisa Ficai Gabriela Petrisor Ovidiu-Cristian Oprea Roxana-Doina Trușcǎ Anton Ficai Ecaterina Andronescu Ariana Hudita Alina Maria Holban |
| author_sort | Ludmila Motelica |
| collection | DOAJ |
| description | <b>Background</b>: Cellulose derivatives are gaining much attention in medical research due to their excellent properties such as biocompatibility, hydrophilicity, non-toxicity, sustainability, and low cost. Unfortunately, cellulose does not exhibit antimicrobial activity. However, derivatives like hydroxyethyl cellulose represent a proper matrix to incorporate antimicrobial agents with beneficial therapeutic effects. <b>Methods</b>: Combining more antimicrobial agents into a single composite material can induce stronger antibacterial activity by synergism. <b>Results</b>: Therefore, we have obtained a hydroxyethyl-cellulose-based material loaded with zinc oxide nanoparticles and cinnamon essential oil as the antimicrobial agents. The cinnamon essential oil was loaded in mesoporous silica particles to control its release. <b>Conclusions</b>: The composite films demonstrated high antibacterial activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> strains, impairing the bacterial cells’ viability and biofilm development. Such antimicrobial films can be used in various biomedical applications such as topical dressings or as packaging for the food industry. |
| format | Article |
| id | doaj-art-9de7e609653e469e94c7b335883ea0b8 |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-9de7e609653e469e94c7b335883ea0b82025-08-20T01:55:46ZengMDPI AGPharmaceutics1999-49232024-09-01169122510.3390/pharmaceutics16091225Antimicrobial Hydroxyethyl-Cellulose-Based Composite Films with Zinc Oxide and Mesoporous Silica Loaded with Cinnamon Essential OilLudmila Motelica0Denisa Ficai1Gabriela Petrisor2Ovidiu-Cristian Oprea3Roxana-Doina Trușcǎ4Anton Ficai5Ecaterina Andronescu6Ariana Hudita7Alina Maria Holban8Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1-7 Gh. Polizu, 011061 Bucharest, RomaniaFaculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1-7 Gh. Polizu, 011061 Bucharest, RomaniaFaculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1-7 Gh. Polizu, 011061 Bucharest, RomaniaFaculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1-7 Gh. Polizu, 011061 Bucharest, RomaniaFaculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1-7 Gh. Polizu, 011061 Bucharest, RomaniaFaculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1-7 Gh. Polizu, 011061 Bucharest, RomaniaFaculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1-7 Gh. Polizu, 011061 Bucharest, RomaniaFaculty of Biology, University of Bucharest, 077206 Bucharest, RomaniaNational Center of Micro and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania<b>Background</b>: Cellulose derivatives are gaining much attention in medical research due to their excellent properties such as biocompatibility, hydrophilicity, non-toxicity, sustainability, and low cost. Unfortunately, cellulose does not exhibit antimicrobial activity. However, derivatives like hydroxyethyl cellulose represent a proper matrix to incorporate antimicrobial agents with beneficial therapeutic effects. <b>Methods</b>: Combining more antimicrobial agents into a single composite material can induce stronger antibacterial activity by synergism. <b>Results</b>: Therefore, we have obtained a hydroxyethyl-cellulose-based material loaded with zinc oxide nanoparticles and cinnamon essential oil as the antimicrobial agents. The cinnamon essential oil was loaded in mesoporous silica particles to control its release. <b>Conclusions</b>: The composite films demonstrated high antibacterial activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> strains, impairing the bacterial cells’ viability and biofilm development. Such antimicrobial films can be used in various biomedical applications such as topical dressings or as packaging for the food industry.https://www.mdpi.com/1999-4923/16/9/1225hydroxyethyl celluloseZnObiodegradable packagingMCM-41cinnamon essential oilantibacterial |
| spellingShingle | Ludmila Motelica Denisa Ficai Gabriela Petrisor Ovidiu-Cristian Oprea Roxana-Doina Trușcǎ Anton Ficai Ecaterina Andronescu Ariana Hudita Alina Maria Holban Antimicrobial Hydroxyethyl-Cellulose-Based Composite Films with Zinc Oxide and Mesoporous Silica Loaded with Cinnamon Essential Oil Pharmaceutics hydroxyethyl cellulose ZnO biodegradable packaging MCM-41 cinnamon essential oil antibacterial |
| title | Antimicrobial Hydroxyethyl-Cellulose-Based Composite Films with Zinc Oxide and Mesoporous Silica Loaded with Cinnamon Essential Oil |
| title_full | Antimicrobial Hydroxyethyl-Cellulose-Based Composite Films with Zinc Oxide and Mesoporous Silica Loaded with Cinnamon Essential Oil |
| title_fullStr | Antimicrobial Hydroxyethyl-Cellulose-Based Composite Films with Zinc Oxide and Mesoporous Silica Loaded with Cinnamon Essential Oil |
| title_full_unstemmed | Antimicrobial Hydroxyethyl-Cellulose-Based Composite Films with Zinc Oxide and Mesoporous Silica Loaded with Cinnamon Essential Oil |
| title_short | Antimicrobial Hydroxyethyl-Cellulose-Based Composite Films with Zinc Oxide and Mesoporous Silica Loaded with Cinnamon Essential Oil |
| title_sort | antimicrobial hydroxyethyl cellulose based composite films with zinc oxide and mesoporous silica loaded with cinnamon essential oil |
| topic | hydroxyethyl cellulose ZnO biodegradable packaging MCM-41 cinnamon essential oil antibacterial |
| url | https://www.mdpi.com/1999-4923/16/9/1225 |
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