6-Gingerol, an active compound of ginger, attenuates NASH-HCC progression by reprogramming tumor-associated macrophage via the NOX2/Src/MAPK signaling pathway

6-Gingerol, an active compound of ginger, attenuates NASH-HCC progression by reprogramming tumor-associated macrophage via the NOX2/Src/MAPK signaling pathway

Abstract Background Non-alcoholic steatohepatitis-associated hepatocellular carcinoma (NASH-HCC) accounts for an increasing proportion of HCC cases. Currently, effective pharmacological options for treating both NASH and NASH-HCC remain limited, necessitating the identification of novel therapeutic...

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Bibliographic Details
Main Authors: Qiurui Li, Meng Wang, Xuekuan Huang, Shang Wang, Chunli Li, Pan Li, Wei Xiang, Ling Yao, Chengdan Deng, Mingming Zhang, Jianwei Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Complementary Medicine and Therapies
Subjects:
6-Gingerol
Tumor-associated macrophages
NASH-HCC
Macrophage reprogramming
Online Access:https://doi.org/10.1186/s12906-025-04890-2
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