Evaluating pregnancy outcomes in women with uterine fibroids treated with high-intensity focused ultrasound: insights from a single-institution study
Abstract Objective This study aims to assess the safety and effectiveness of High-Intensity Focused Ultrasound (HIFU) ablation on pregnancy outcomes among women with uterine fibroids wishing to conceive, focusing specifically on short-term pregnancy outcomes immediately following HIFU treatment. Met...
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BMC
2024-12-01
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| Series: | Reproductive Health |
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| Online Access: | https://doi.org/10.1186/s12978-024-01930-x |
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| author | Min Zhao Dan Wang Yong Zhang Ligang Wang |
| author_facet | Min Zhao Dan Wang Yong Zhang Ligang Wang |
| author_sort | Min Zhao |
| collection | DOAJ |
| description | Abstract Objective This study aims to assess the safety and effectiveness of High-Intensity Focused Ultrasound (HIFU) ablation on pregnancy outcomes among women with uterine fibroids wishing to conceive, focusing specifically on short-term pregnancy outcomes immediately following HIFU treatment. Methods A retrospective analysis was conducted on 210 women who underwent HIFU treatment (Group I) at our institution between January 2018 and December 2022 and subsequently conceived. Pregnancy outcomes were compared with two control groups: 510 patients who delivered vaginally (Group II) and 278 who underwent cesarean sections (Group III) during the same period. Statistical analyses included multivariable logistic regression to adjust for confounding factors. The study only considered outcomes related to the immediate pregnancy following HIFU treatment and did not include data on subsequent pregnancies or long-term effects. Results The natural conception rate post-HIFU was 93.81% (197/210), with a miscarriage rate of 19.05% (40/210). Group I had significantly lower rates of gestational diabetes mellitus (8.24%) and precipitate labor (0%) compared to Group II but higher rates of mild anemia (31.18%) and adherent placenta (10.59%). Compared to Group III, Group I had lower rates of gestational diabetes mellitus (8.24% vs. 20.86%) and moderate anemia (4.71% vs. 16.55%) but a higher incidence of premature rupture of membranes (18.82%). Neonates in Group I had lower birth weights compared to Groups II and III (p < 0.05), with no cases of low birth weight in Group I. Multivariable analysis identified fibroid location as a predictor of preterm birth, while maternal age and mode of delivery influenced the risk of incomplete uterine rupture. Conclusion HIFU ablation is a safe and effective fertility-preserving treatment for women with uterine fibroids, demonstrating favorable short-term pregnancy outcomes. It does not increase perinatal risks, but its impact on pregnancy duration and certain complications suggests that careful patient selection and management are crucial. Future studies should investigate the long-term effects of HIFU on subsequent pregnancies. |
| format | Article |
| id | doaj-art-9de49c3a17d64e2aab7896baba6d9549 |
| institution | DOAJ |
| issn | 1742-4755 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | Reproductive Health |
| spelling | doaj-art-9de49c3a17d64e2aab7896baba6d95492025-08-20T02:39:48ZengBMCReproductive Health1742-47552024-12-0121111110.1186/s12978-024-01930-xEvaluating pregnancy outcomes in women with uterine fibroids treated with high-intensity focused ultrasound: insights from a single-institution studyMin Zhao0Dan Wang1Yong Zhang2Ligang Wang3Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaAbstract Objective This study aims to assess the safety and effectiveness of High-Intensity Focused Ultrasound (HIFU) ablation on pregnancy outcomes among women with uterine fibroids wishing to conceive, focusing specifically on short-term pregnancy outcomes immediately following HIFU treatment. Methods A retrospective analysis was conducted on 210 women who underwent HIFU treatment (Group I) at our institution between January 2018 and December 2022 and subsequently conceived. Pregnancy outcomes were compared with two control groups: 510 patients who delivered vaginally (Group II) and 278 who underwent cesarean sections (Group III) during the same period. Statistical analyses included multivariable logistic regression to adjust for confounding factors. The study only considered outcomes related to the immediate pregnancy following HIFU treatment and did not include data on subsequent pregnancies or long-term effects. Results The natural conception rate post-HIFU was 93.81% (197/210), with a miscarriage rate of 19.05% (40/210). Group I had significantly lower rates of gestational diabetes mellitus (8.24%) and precipitate labor (0%) compared to Group II but higher rates of mild anemia (31.18%) and adherent placenta (10.59%). Compared to Group III, Group I had lower rates of gestational diabetes mellitus (8.24% vs. 20.86%) and moderate anemia (4.71% vs. 16.55%) but a higher incidence of premature rupture of membranes (18.82%). Neonates in Group I had lower birth weights compared to Groups II and III (p < 0.05), with no cases of low birth weight in Group I. Multivariable analysis identified fibroid location as a predictor of preterm birth, while maternal age and mode of delivery influenced the risk of incomplete uterine rupture. Conclusion HIFU ablation is a safe and effective fertility-preserving treatment for women with uterine fibroids, demonstrating favorable short-term pregnancy outcomes. It does not increase perinatal risks, but its impact on pregnancy duration and certain complications suggests that careful patient selection and management are crucial. Future studies should investigate the long-term effects of HIFU on subsequent pregnancies.https://doi.org/10.1186/s12978-024-01930-xUterine fibroidsHigh-intensity focused ultrasoundPregnancy outcomesFertility preservationObstetric complications |
| spellingShingle | Min Zhao Dan Wang Yong Zhang Ligang Wang Evaluating pregnancy outcomes in women with uterine fibroids treated with high-intensity focused ultrasound: insights from a single-institution study Reproductive Health Uterine fibroids High-intensity focused ultrasound Pregnancy outcomes Fertility preservation Obstetric complications |
| title | Evaluating pregnancy outcomes in women with uterine fibroids treated with high-intensity focused ultrasound: insights from a single-institution study |
| title_full | Evaluating pregnancy outcomes in women with uterine fibroids treated with high-intensity focused ultrasound: insights from a single-institution study |
| title_fullStr | Evaluating pregnancy outcomes in women with uterine fibroids treated with high-intensity focused ultrasound: insights from a single-institution study |
| title_full_unstemmed | Evaluating pregnancy outcomes in women with uterine fibroids treated with high-intensity focused ultrasound: insights from a single-institution study |
| title_short | Evaluating pregnancy outcomes in women with uterine fibroids treated with high-intensity focused ultrasound: insights from a single-institution study |
| title_sort | evaluating pregnancy outcomes in women with uterine fibroids treated with high intensity focused ultrasound insights from a single institution study |
| topic | Uterine fibroids High-intensity focused ultrasound Pregnancy outcomes Fertility preservation Obstetric complications |
| url | https://doi.org/10.1186/s12978-024-01930-x |
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