The Importance of Klebsiella pneumoniae as a Pathogen and the Increasing Prevalence of Antibiotic-Resistant Strains and Molecular Characteristics
Klebsiella pneumoniae is a significant pathogen causing various infections, and antibiotic-resistant strains of K.pneumoniae are becoming more prevalent. Molecular studies reveal the genetic mechanisms underlying antibiotic resistance, such as resistance genes on plasmids that can easily spread betw...
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| Format: | Article |
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College of Medicine, Al-Nahrain University
2023-12-01
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| Series: | Baghdad Journal of Biochemistry and Applied Biological Sciences |
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| Online Access: | https://bjbabs.org/index.php/bjbabs/article/view/211 |
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| author | Waleed Mohammed Fatimah Abdulazeez Awad Thana I. Mustafa |
| author_facet | Waleed Mohammed Fatimah Abdulazeez Awad Thana I. Mustafa |
| author_sort | Waleed Mohammed |
| collection | DOAJ |
| description | Klebsiella pneumoniae is a significant pathogen causing various infections, and antibiotic-resistant strains of K.pneumoniae are becoming more prevalent. Molecular studies reveal the genetic mechanisms underlying antibiotic resistance, such as resistance genes on plasmids that can easily spread between bacteria. Knowledge of the molecular characteristics of antibiotic-resistant strains is crucial to develop effective strategies against their spread. The bacteria can easy colonizes the human gut and can also cause a range of infections, including pneumonia, urinary tract infections, and bloodstream infections.
The emergence of antibiotic-resistant strains of K.pneumoniae has become a major public health concern, as these strains are associated with increased morbidity and mortality rates, longer hospital stays, and higher healthcare costs. Antibiotic resistance in K.pneumoniae involves several mechanisms, including beta-lactamase production, changes in outer membrane porins, and the uptake of resistance genes via horizontal gene transfer.
The genetics and genomics of K.pneumoniae are also of significant interest, as they provide insights into the diversity of strains and their pathogenic potential. Genome sequencing has revealed the existence of distinct lineages of K. pneumoniae, each with unique virulence factors and antimicrobial resistance profiles.
To summarize, K.pneumoniae is a critical pathogen that poses a substantial global public health threat. The rising prevalence of antibiotic-resistant strains underscores the pressing need for innovative approaches to prevent and treat K.pneumoniae infections. Comprehensive knowledge of the molecular mechanisms of virulence, pathogenicity, and antibiotic resistance, as well as the genetic diversity of K. pneumoniae, will be essential in developing effective strategies to combat this pathogen. |
| format | Article |
| id | doaj-art-9de24aa6da26433cb8c978b82e4f2a4a |
| institution | OA Journals |
| issn | 2706-9915 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | College of Medicine, Al-Nahrain University |
| record_format | Article |
| series | Baghdad Journal of Biochemistry and Applied Biological Sciences |
| spelling | doaj-art-9de24aa6da26433cb8c978b82e4f2a4a2025-08-20T02:25:44ZengCollege of Medicine, Al-Nahrain UniversityBaghdad Journal of Biochemistry and Applied Biological Sciences2706-99152023-12-014418020310.47419/bjbabs.v4i04.211The Importance of Klebsiella pneumoniae as a Pathogen and the Increasing Prevalence of Antibiotic-Resistant Strains and Molecular CharacteristicsWaleed Mohammed0Fatimah Abdulazeez Awad1Thana I. Mustafa2Department of Basic Science, College of Dentistry, University of Anbar, Anbar, IraqDepartment of Basic Science, College of Dentistry , University Of Anbar , Ramadi, IraqDepartment of Basic Science, College of Dentistry , University Of Anbar , Ramadi, IraqKlebsiella pneumoniae is a significant pathogen causing various infections, and antibiotic-resistant strains of K.pneumoniae are becoming more prevalent. Molecular studies reveal the genetic mechanisms underlying antibiotic resistance, such as resistance genes on plasmids that can easily spread between bacteria. Knowledge of the molecular characteristics of antibiotic-resistant strains is crucial to develop effective strategies against their spread. The bacteria can easy colonizes the human gut and can also cause a range of infections, including pneumonia, urinary tract infections, and bloodstream infections. The emergence of antibiotic-resistant strains of K.pneumoniae has become a major public health concern, as these strains are associated with increased morbidity and mortality rates, longer hospital stays, and higher healthcare costs. Antibiotic resistance in K.pneumoniae involves several mechanisms, including beta-lactamase production, changes in outer membrane porins, and the uptake of resistance genes via horizontal gene transfer. The genetics and genomics of K.pneumoniae are also of significant interest, as they provide insights into the diversity of strains and their pathogenic potential. Genome sequencing has revealed the existence of distinct lineages of K. pneumoniae, each with unique virulence factors and antimicrobial resistance profiles. To summarize, K.pneumoniae is a critical pathogen that poses a substantial global public health threat. The rising prevalence of antibiotic-resistant strains underscores the pressing need for innovative approaches to prevent and treat K.pneumoniae infections. Comprehensive knowledge of the molecular mechanisms of virulence, pathogenicity, and antibiotic resistance, as well as the genetic diversity of K. pneumoniae, will be essential in developing effective strategies to combat this pathogen.https://bjbabs.org/index.php/bjbabs/article/view/211mechanisms of antibiotic resistancentibiotic-resistant strainsk.pneumoniaemolecular characteristicsgeneticsgene transfer mechanisms |
| spellingShingle | Waleed Mohammed Fatimah Abdulazeez Awad Thana I. Mustafa The Importance of Klebsiella pneumoniae as a Pathogen and the Increasing Prevalence of Antibiotic-Resistant Strains and Molecular Characteristics Baghdad Journal of Biochemistry and Applied Biological Sciences mechanisms of antibiotic resistance ntibiotic-resistant strains k.pneumoniae molecular characteristics genetics gene transfer mechanisms |
| title | The Importance of Klebsiella pneumoniae as a Pathogen and the Increasing Prevalence of Antibiotic-Resistant Strains and Molecular Characteristics |
| title_full | The Importance of Klebsiella pneumoniae as a Pathogen and the Increasing Prevalence of Antibiotic-Resistant Strains and Molecular Characteristics |
| title_fullStr | The Importance of Klebsiella pneumoniae as a Pathogen and the Increasing Prevalence of Antibiotic-Resistant Strains and Molecular Characteristics |
| title_full_unstemmed | The Importance of Klebsiella pneumoniae as a Pathogen and the Increasing Prevalence of Antibiotic-Resistant Strains and Molecular Characteristics |
| title_short | The Importance of Klebsiella pneumoniae as a Pathogen and the Increasing Prevalence of Antibiotic-Resistant Strains and Molecular Characteristics |
| title_sort | importance of klebsiella pneumoniae as a pathogen and the increasing prevalence of antibiotic resistant strains and molecular characteristics |
| topic | mechanisms of antibiotic resistance ntibiotic-resistant strains k.pneumoniae molecular characteristics genetics gene transfer mechanisms |
| url | https://bjbabs.org/index.php/bjbabs/article/view/211 |
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