Sterile Inflammation in Drosophila
The study of immune responses in Drosophila has already yielded significant results with impacts on our understanding of vertebrate immunity, such as the characterization of the Toll receptor. Several recent papers have focused on the humoral response to damage signals rather than pathogens, particu...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/369286 |
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| _version_ | 1850170493192110080 |
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| author | Zeeshan Shaukat Dawei Liu Stephen Gregory |
| author_facet | Zeeshan Shaukat Dawei Liu Stephen Gregory |
| author_sort | Zeeshan Shaukat |
| collection | DOAJ |
| description | The study of immune responses in Drosophila has already yielded significant results with impacts on our understanding of vertebrate immunity, such as the characterization of the Toll receptor. Several recent papers have focused on the humoral response to damage signals rather than pathogens, particularly damage signals from tumour-like tissues generated by loss of cell polarity or chromosomal instability. Both the triggers that generate this sterile inflammation and the systemic and local effects of it are only just beginning to be characterized in Drosophila. Here we review the molecular mechanisms that are known that give rise to the recruitment of Drosophila phagocytes, called hemocytes, as well as the signals, such as TNFα, that stimulated hemocytes emit at sites of perceived damage. The signalling consequences of inflammation, such as the activation of JNK, and the potential for modifying this response are also discussed. |
| format | Article |
| id | doaj-art-9de0f01aadd14a6791b258dada869e8e |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9de0f01aadd14a6791b258dada869e8e2025-08-20T02:20:29ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/369286369286Sterile Inflammation in DrosophilaZeeshan Shaukat0Dawei Liu1Stephen Gregory2School of Biological Sciences, University of Adelaide, North Terrace, Adelaide, SA 5006, AustraliaSchool of Biological Sciences, University of Adelaide, North Terrace, Adelaide, SA 5006, AustraliaSchool of Biological Sciences, University of Adelaide, North Terrace, Adelaide, SA 5006, AustraliaThe study of immune responses in Drosophila has already yielded significant results with impacts on our understanding of vertebrate immunity, such as the characterization of the Toll receptor. Several recent papers have focused on the humoral response to damage signals rather than pathogens, particularly damage signals from tumour-like tissues generated by loss of cell polarity or chromosomal instability. Both the triggers that generate this sterile inflammation and the systemic and local effects of it are only just beginning to be characterized in Drosophila. Here we review the molecular mechanisms that are known that give rise to the recruitment of Drosophila phagocytes, called hemocytes, as well as the signals, such as TNFα, that stimulated hemocytes emit at sites of perceived damage. The signalling consequences of inflammation, such as the activation of JNK, and the potential for modifying this response are also discussed.http://dx.doi.org/10.1155/2015/369286 |
| spellingShingle | Zeeshan Shaukat Dawei Liu Stephen Gregory Sterile Inflammation in Drosophila Mediators of Inflammation |
| title | Sterile Inflammation in Drosophila |
| title_full | Sterile Inflammation in Drosophila |
| title_fullStr | Sterile Inflammation in Drosophila |
| title_full_unstemmed | Sterile Inflammation in Drosophila |
| title_short | Sterile Inflammation in Drosophila |
| title_sort | sterile inflammation in drosophila |
| url | http://dx.doi.org/10.1155/2015/369286 |
| work_keys_str_mv | AT zeeshanshaukat sterileinflammationindrosophila AT daweiliu sterileinflammationindrosophila AT stephengregory sterileinflammationindrosophila |