Enhancing medical AI with retrieval-augmented generation: A mini narrative review
Retrieval-augmented generation (RAG) is a powerful technique in artificial intelligence (AI) and machine learning that enhances the capabilities of large language models (LLMs) by integrating external data sources, allowing for more accurate, contextually relevant responses. In medical applications,...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-04-01
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| Series: | Digital Health |
| Online Access: | https://doi.org/10.1177/20552076251337177 |
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| author | Omid Kohandel Gargari Gholamreza Habibi |
| author_facet | Omid Kohandel Gargari Gholamreza Habibi |
| author_sort | Omid Kohandel Gargari |
| collection | DOAJ |
| description | Retrieval-augmented generation (RAG) is a powerful technique in artificial intelligence (AI) and machine learning that enhances the capabilities of large language models (LLMs) by integrating external data sources, allowing for more accurate, contextually relevant responses. In medical applications, RAG has the potential to improve diagnostic accuracy, clinical decision support, and patient care. This narrative review explores the application of RAG across various medical domains, including guideline interpretation, diagnostic assistance, clinical trial eligibility screening, clinical information retrieval, and information extraction from scientific literature. Studies highlight the benefits of RAG in providing accurate, up-to-date information, improving clinical outcomes, and streamlining processes. Notable applications include GPT-4 models enhanced with RAG to interpret hepatologic guidelines, assist in differential diagnosis, and aid in clinical trial screening. Furthermore, RAG-based systems have demonstrated superior performance over traditional methods in tasks such as patient diagnosis, clinical decision-making, and medical information extraction. Despite its advantages, challenges remain, particularly in model evaluation, cost-efficiency, and reducing AI hallucinations. This review emphasizes the potential of RAG in advancing medical AI applications and advocates for further optimization of retrieval mechanisms, embedding models, and collaboration between AI researchers and healthcare professionals to maximize RAG's impact on medical practice. |
| format | Article |
| id | doaj-art-9ddbde19d8bf45e5b4f9e26b2f1cee18 |
| institution | DOAJ |
| issn | 2055-2076 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Digital Health |
| spelling | doaj-art-9ddbde19d8bf45e5b4f9e26b2f1cee182025-08-20T02:57:44ZengSAGE PublishingDigital Health2055-20762025-04-011110.1177/20552076251337177Enhancing medical AI with retrieval-augmented generation: A mini narrative reviewOmid Kohandel GargariGholamreza HabibiRetrieval-augmented generation (RAG) is a powerful technique in artificial intelligence (AI) and machine learning that enhances the capabilities of large language models (LLMs) by integrating external data sources, allowing for more accurate, contextually relevant responses. In medical applications, RAG has the potential to improve diagnostic accuracy, clinical decision support, and patient care. This narrative review explores the application of RAG across various medical domains, including guideline interpretation, diagnostic assistance, clinical trial eligibility screening, clinical information retrieval, and information extraction from scientific literature. Studies highlight the benefits of RAG in providing accurate, up-to-date information, improving clinical outcomes, and streamlining processes. Notable applications include GPT-4 models enhanced with RAG to interpret hepatologic guidelines, assist in differential diagnosis, and aid in clinical trial screening. Furthermore, RAG-based systems have demonstrated superior performance over traditional methods in tasks such as patient diagnosis, clinical decision-making, and medical information extraction. Despite its advantages, challenges remain, particularly in model evaluation, cost-efficiency, and reducing AI hallucinations. This review emphasizes the potential of RAG in advancing medical AI applications and advocates for further optimization of retrieval mechanisms, embedding models, and collaboration between AI researchers and healthcare professionals to maximize RAG's impact on medical practice.https://doi.org/10.1177/20552076251337177 |
| spellingShingle | Omid Kohandel Gargari Gholamreza Habibi Enhancing medical AI with retrieval-augmented generation: A mini narrative review Digital Health |
| title | Enhancing medical AI with retrieval-augmented generation: A mini narrative review |
| title_full | Enhancing medical AI with retrieval-augmented generation: A mini narrative review |
| title_fullStr | Enhancing medical AI with retrieval-augmented generation: A mini narrative review |
| title_full_unstemmed | Enhancing medical AI with retrieval-augmented generation: A mini narrative review |
| title_short | Enhancing medical AI with retrieval-augmented generation: A mini narrative review |
| title_sort | enhancing medical ai with retrieval augmented generation a mini narrative review |
| url | https://doi.org/10.1177/20552076251337177 |
| work_keys_str_mv | AT omidkohandelgargari enhancingmedicalaiwithretrievalaugmentedgenerationamininarrativereview AT gholamrezahabibi enhancingmedicalaiwithretrievalaugmentedgenerationamininarrativereview |