Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms
This review summarizes the correlation between diabetes mellitus (DM) and gastric cancer (GC) from the perspectives of epidemiology, drug use, and potential mechanisms. The association between DM and GC is inconclusive, and the positive direction of the association reported in most published meta-an...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2023/4388437 |
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| _version_ | 1849398965978529792 |
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| author | Li Wang Zhe Zhang |
| author_facet | Li Wang Zhe Zhang |
| author_sort | Li Wang |
| collection | DOAJ |
| description | This review summarizes the correlation between diabetes mellitus (DM) and gastric cancer (GC) from the perspectives of epidemiology, drug use, and potential mechanisms. The association between DM and GC is inconclusive, and the positive direction of the association reported in most published meta-analyses suggests that DM may be an independent risk factor for GC. Many clinical investigations have shown that people with DM and GC who undergo gastrectomy may have better glycemic control. The potential link between DM and GC may involve the interaction of multiple common risk factors, such as obesity, hyperglycemia and hyperinsulinemia, H. pylori infection, and the use of metformin. Although in vitro and in vivo data support that H. pylori infection status and metformin can influence GC risk in DM patients, there are conflicting results. Patient survival outcomes are influenced by multiple factors, so further research is needed to identify the patients who may benefit. |
| format | Article |
| id | doaj-art-9dda3be2122a4fca863d35cd2d50929e |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-9dda3be2122a4fca863d35cd2d50929e2025-08-20T03:38:26ZengWileyJournal of Diabetes Research2314-67532023-01-01202310.1155/2023/4388437Diabetes Mellitus and Gastric Cancer: Correlation and Potential MechanismsLi Wang0Zhe Zhang1Department of EmergencyDepartment of Emergency MedicineThis review summarizes the correlation between diabetes mellitus (DM) and gastric cancer (GC) from the perspectives of epidemiology, drug use, and potential mechanisms. The association between DM and GC is inconclusive, and the positive direction of the association reported in most published meta-analyses suggests that DM may be an independent risk factor for GC. Many clinical investigations have shown that people with DM and GC who undergo gastrectomy may have better glycemic control. The potential link between DM and GC may involve the interaction of multiple common risk factors, such as obesity, hyperglycemia and hyperinsulinemia, H. pylori infection, and the use of metformin. Although in vitro and in vivo data support that H. pylori infection status and metformin can influence GC risk in DM patients, there are conflicting results. Patient survival outcomes are influenced by multiple factors, so further research is needed to identify the patients who may benefit.http://dx.doi.org/10.1155/2023/4388437 |
| spellingShingle | Li Wang Zhe Zhang Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms Journal of Diabetes Research |
| title | Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms |
| title_full | Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms |
| title_fullStr | Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms |
| title_full_unstemmed | Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms |
| title_short | Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms |
| title_sort | diabetes mellitus and gastric cancer correlation and potential mechanisms |
| url | http://dx.doi.org/10.1155/2023/4388437 |
| work_keys_str_mv | AT liwang diabetesmellitusandgastriccancercorrelationandpotentialmechanisms AT zhezhang diabetesmellitusandgastriccancercorrelationandpotentialmechanisms |