Evaluation of patients with Tularemia in Bolu province in northwestern Anatolia, Turkey
Introduction: Tularemia is a zoonotic disease caused by Francisella tularensis. Here we present an epidemic occurring in Bolu province, located in northwestern Anatolia in Turkey, and some features of the cases. Methodology: The data was provided by the Bolu Provincial Health Directorate. All of th...
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The Journal of Infection in Developing Countries
2014-03-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/3952 |
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| author | Zafer Mengeloglu Arif Duran Ismail Necati Hakyemez Tarik Ocak Abdülkadir Kücükbayrak Mustafa Karadag Tekin Tas Hayrettin Akdeniz |
| author_facet | Zafer Mengeloglu Arif Duran Ismail Necati Hakyemez Tarik Ocak Abdülkadir Kücükbayrak Mustafa Karadag Tekin Tas Hayrettin Akdeniz |
| author_sort | Zafer Mengeloglu |
| collection | DOAJ |
| description | Introduction: Tularemia is a zoonotic disease caused by Francisella tularensis. Here we present an epidemic occurring in Bolu province, located in northwestern Anatolia in Turkey, and some features of the cases.
Methodology: The data was provided by the Bolu Provincial Health Directorate. All of the antibody response tests were studied in the National Health Institute (formerly named Refik Saydam Hygiene Department), the reference laboratory of the Ministry of Health of the Turkish Republic. A total of 393 individuals were tested by microagglutination test (MAT) for tularemia between 2006 and 2011. A total of 218 patients whose demographical data were available were included in the study; 83 were accepted as the patient group and 135 were the controls. Of the patients, 31 (37.3%) were male and 52 (62.7%) were female.
Results: Fever (p < 0.001), URTI symptoms (p = 0.047), conjunctivitis (p = 0.004), and rash (p = 0.026) were significantly higher in the patient group. A positive association was found between MAT and fever (r = 0.324; p < 0.001), and a negative association was found between MAT and both lymphoadenopathy (r = -0.25; p = 0.013) and chills (r = -0.218; p = 0.035). Higher MAT titers were detected in oropharyngeal tularemia (r = 0.306; p = 0.003).
Conclusions: In conclusion, tularemia must be considered in differential diagnosis in patients presenting with fever and LAP in non-endemic regions. Furthermore, water sources and contact with rodents must be investigated. |
| format | Article |
| id | doaj-art-9dd86e7ce171425a8bcdb212f89f1e12 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2014-03-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-9dd86e7ce171425a8bcdb212f89f1e122025-08-20T02:57:53ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802014-03-0180310.3855/jidc.3952Evaluation of patients with Tularemia in Bolu province in northwestern Anatolia, TurkeyZafer Mengeloglu0Arif Duran1Ismail Necati Hakyemez2Tarik Ocak3Abdülkadir Kücükbayrak4Mustafa Karadag5Tekin Tas6Hayrettin Akdeniz7Abant Izzet Baysal University, Faculty of Medicine, Bolu, TurkeyAbant Izzet Baysal University, Faculty of Medicine, Bolu, TurkeyBezmialem University, Faculty of Medicine, Istanbul, TurkeyAbant Izzet Baysal University, Faculty of Medicine, Bolu, TurkeyAbant Izzet Baysal University, Faculty of Medicine, Bolu, TurkeyBolu Provinceal Health Directorate, Bolu, TurkeyAbant Izzet Baysal University, Faculty of Medicine, Bolu, TurkeyAbant Izzet Baysal University, Faculty of Medicine, Bolu, TurkeyIntroduction: Tularemia is a zoonotic disease caused by Francisella tularensis. Here we present an epidemic occurring in Bolu province, located in northwestern Anatolia in Turkey, and some features of the cases. Methodology: The data was provided by the Bolu Provincial Health Directorate. All of the antibody response tests were studied in the National Health Institute (formerly named Refik Saydam Hygiene Department), the reference laboratory of the Ministry of Health of the Turkish Republic. A total of 393 individuals were tested by microagglutination test (MAT) for tularemia between 2006 and 2011. A total of 218 patients whose demographical data were available were included in the study; 83 were accepted as the patient group and 135 were the controls. Of the patients, 31 (37.3%) were male and 52 (62.7%) were female. Results: Fever (p < 0.001), URTI symptoms (p = 0.047), conjunctivitis (p = 0.004), and rash (p = 0.026) were significantly higher in the patient group. A positive association was found between MAT and fever (r = 0.324; p < 0.001), and a negative association was found between MAT and both lymphoadenopathy (r = -0.25; p = 0.013) and chills (r = -0.218; p = 0.035). Higher MAT titers were detected in oropharyngeal tularemia (r = 0.306; p = 0.003). Conclusions: In conclusion, tularemia must be considered in differential diagnosis in patients presenting with fever and LAP in non-endemic regions. Furthermore, water sources and contact with rodents must be investigated.https://jidc.org/index.php/journal/article/view/3952tularemiaTurkeyBolumicroagglutination |
| spellingShingle | Zafer Mengeloglu Arif Duran Ismail Necati Hakyemez Tarik Ocak Abdülkadir Kücükbayrak Mustafa Karadag Tekin Tas Hayrettin Akdeniz Evaluation of patients with Tularemia in Bolu province in northwestern Anatolia, Turkey Journal of Infection in Developing Countries tularemia Turkey Bolu microagglutination |
| title | Evaluation of patients with Tularemia in Bolu province in northwestern Anatolia, Turkey |
| title_full | Evaluation of patients with Tularemia in Bolu province in northwestern Anatolia, Turkey |
| title_fullStr | Evaluation of patients with Tularemia in Bolu province in northwestern Anatolia, Turkey |
| title_full_unstemmed | Evaluation of patients with Tularemia in Bolu province in northwestern Anatolia, Turkey |
| title_short | Evaluation of patients with Tularemia in Bolu province in northwestern Anatolia, Turkey |
| title_sort | evaluation of patients with tularemia in bolu province in northwestern anatolia turkey |
| topic | tularemia Turkey Bolu microagglutination |
| url | https://jidc.org/index.php/journal/article/view/3952 |
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