Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions

Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions

Abstract RAD51C is a tumor suppressor gene with over 285 variants of unknown significance (VUS) found in primary ovarian tumors. RAD51C is a paralog of the recombinase RAD51, and it forms complexes with other paralogs to regulate RAD51 activity. We screened 27 ovarian cancer-derived RAD51C VUS to id...

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Main Authors: Hayley L. Rein, Yashpal Rawal, Anna L. Palovcak-Lightbourn, Gayatri S. Ganesan, Phoebe S. Parker, Reagan Russell, Kristie E. Darrah, Mohammad Afsar, Meghan R. Sullivan, Sarah R. Hengel, Marc R. Radke, Patricia L. Opresko, Judith L. Yanowitz, Eric C. Greene, Jung-Min Lee, Susan M. Domchek, Elizabeth M. Swisher, Shaun K. Olsen, Patrick Sung, Kara A. Bernstein
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61283-2
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