In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems
In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H2, NO, and H2S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on e...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0775 |
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| author | Chenyu Zong Fei Wang Wenguo Cui |
| author_facet | Chenyu Zong Fei Wang Wenguo Cui |
| author_sort | Chenyu Zong |
| collection | DOAJ |
| description | In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H2, NO, and H2S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H2S-mediated anti-inflammation) to modulate disease microenvironments. The system’s biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery. |
| format | Article |
| id | doaj-art-9dd55b07c6774dcdba6077ba6f4a3149 |
| institution | DOAJ |
| issn | 2639-5274 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj-art-9dd55b07c6774dcdba6077ba6f4a31492025-08-20T03:05:38ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742025-01-01810.34133/research.0775In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery SystemsChenyu Zong0Fei Wang1Wenguo Cui2Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H2, NO, and H2S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H2S-mediated anti-inflammation) to modulate disease microenvironments. The system’s biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.https://spj.science.org/doi/10.34133/research.0775 |
| spellingShingle | Chenyu Zong Fei Wang Wenguo Cui In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems Research |
| title | In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems |
| title_full | In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems |
| title_fullStr | In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems |
| title_full_unstemmed | In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems |
| title_short | In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems |
| title_sort | in situ microbial aerodynamic microneedles for targeted drug delivery systems |
| url | https://spj.science.org/doi/10.34133/research.0775 |
| work_keys_str_mv | AT chenyuzong insitumicrobialaerodynamicmicroneedlesfortargeteddrugdeliverysystems AT feiwang insitumicrobialaerodynamicmicroneedlesfortargeteddrugdeliverysystems AT wenguocui insitumicrobialaerodynamicmicroneedlesfortargeteddrugdeliverysystems |