Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular‐Kidney‐Metabolic Syndrome Among the General Adult Population
ABSTRACT Objective To examine the relationship between serum carotenoid levels and cardiovascular‐kidney‐metabolic (CKM) syndrome in a representative sample of US adults. Methods Data from the fasting subsample of the NHANES 2017–2018 were analyzed using a survey‐weighted approach to ensure the find...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-02-01
|
| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.70046 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850077804422496256 |
|---|---|
| author | Mengli Chen Shuyue Cai Qinfeng Jia Yifang Suo Yuan Tang Yanping Shi Xu Zhu Haifeng Zhang |
| author_facet | Mengli Chen Shuyue Cai Qinfeng Jia Yifang Suo Yuan Tang Yanping Shi Xu Zhu Haifeng Zhang |
| author_sort | Mengli Chen |
| collection | DOAJ |
| description | ABSTRACT Objective To examine the relationship between serum carotenoid levels and cardiovascular‐kidney‐metabolic (CKM) syndrome in a representative sample of US adults. Methods Data from the fasting subsample of the NHANES 2017–2018 were analyzed using a survey‐weighted approach to ensure the findings are representative of the broader US adult population. Serum levels of α‐carotene, β‐carotene, β‐cryptoxanthin, lutein/zeaxanthin, and lycopene were measured using high‐performance liquid chromatography. CKM syndrome stages were defined according to the 2023 American Heart Association guidelines, with advanced CKM syndrome categorized as stages 3 or 4. Associations between serum carotenoids and advanced CKM syndrome were assessed using logistic regression and weighted quantile sum (WQS) regression. Results The study included 1671 adults aged 20 years and older, with a mean age of 48.7 years and a gender distribution of 50.9% female and 49.1% male. Higher serum levels of α‐carotene, β‐carotene, α‐cryptoxanthin, lutein/zeaxanthin, and lycopene were inversely associated with advanced CKM syndrome. Specifically, compared to the lowest quartile, the highest quartile of α‐carotene had an odds ratio (OR) of 0.29 (95% CI: 0.16–0.55), β‐carotene 0.35 (95% CI: 0.16–0.78), α‐cryptoxanthin 0.23 (95% CI: 0.11–0.49), lutein/zeaxanthin 0.26 (95% CI: 0.14–0.48), and lycopene 0.58 (95% CI: 0.35–0.98). However, β‐cryptoxanthin did not show a significant association. Moreover, the combined effect of all carotenoids was significantly negatively correlated with advanced CKM syndrome (OR = 0.67, 95% CI: 0.53–0.86), with lutein/zeaxanthin contributing the most (44.56%). Conclusions Elevated serum carotenoid levels are inversely associated with the prevalence of advanced CKM syndrome in a dose‐dependent manner, with this association remaining consistent across diverse demographic and health subgroups. |
| format | Article |
| id | doaj-art-9dcdbe25c54b49599da0963d3dc3e8b3 |
| institution | DOAJ |
| issn | 1753-0393 1753-0407 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj-art-9dcdbe25c54b49599da0963d3dc3e8b32025-08-20T02:45:43ZengWileyJournal of Diabetes1753-03931753-04072025-02-01172n/an/a10.1111/1753-0407.70046Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular‐Kidney‐Metabolic Syndrome Among the General Adult PopulationMengli Chen0Shuyue Cai1Qinfeng Jia2Yifang Suo3Yuan Tang4Yanping Shi5Xu Zhu6Haifeng Zhang7Department of Cardiology The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou ChinaDepartment of Cardiology The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou ChinaDepartment of Cardiology The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou ChinaDepartment of Cardiology The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou ChinaDepartment of Cardiology The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou ChinaDepartment of Cardiology The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou ChinaState Key Laboratory for Innovation and Transformation of Luobing Theory, Department of Cardiology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaDepartment of Cardiology The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou ChinaABSTRACT Objective To examine the relationship between serum carotenoid levels and cardiovascular‐kidney‐metabolic (CKM) syndrome in a representative sample of US adults. Methods Data from the fasting subsample of the NHANES 2017–2018 were analyzed using a survey‐weighted approach to ensure the findings are representative of the broader US adult population. Serum levels of α‐carotene, β‐carotene, β‐cryptoxanthin, lutein/zeaxanthin, and lycopene were measured using high‐performance liquid chromatography. CKM syndrome stages were defined according to the 2023 American Heart Association guidelines, with advanced CKM syndrome categorized as stages 3 or 4. Associations between serum carotenoids and advanced CKM syndrome were assessed using logistic regression and weighted quantile sum (WQS) regression. Results The study included 1671 adults aged 20 years and older, with a mean age of 48.7 years and a gender distribution of 50.9% female and 49.1% male. Higher serum levels of α‐carotene, β‐carotene, α‐cryptoxanthin, lutein/zeaxanthin, and lycopene were inversely associated with advanced CKM syndrome. Specifically, compared to the lowest quartile, the highest quartile of α‐carotene had an odds ratio (OR) of 0.29 (95% CI: 0.16–0.55), β‐carotene 0.35 (95% CI: 0.16–0.78), α‐cryptoxanthin 0.23 (95% CI: 0.11–0.49), lutein/zeaxanthin 0.26 (95% CI: 0.14–0.48), and lycopene 0.58 (95% CI: 0.35–0.98). However, β‐cryptoxanthin did not show a significant association. Moreover, the combined effect of all carotenoids was significantly negatively correlated with advanced CKM syndrome (OR = 0.67, 95% CI: 0.53–0.86), with lutein/zeaxanthin contributing the most (44.56%). Conclusions Elevated serum carotenoid levels are inversely associated with the prevalence of advanced CKM syndrome in a dose‐dependent manner, with this association remaining consistent across diverse demographic and health subgroups.https://doi.org/10.1111/1753-0407.70046cardiovascular diseasecarotenoidskidney diseasemetabolic syndromeNHANESWQS |
| spellingShingle | Mengli Chen Shuyue Cai Qinfeng Jia Yifang Suo Yuan Tang Yanping Shi Xu Zhu Haifeng Zhang Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular‐Kidney‐Metabolic Syndrome Among the General Adult Population Journal of Diabetes cardiovascular disease carotenoids kidney disease metabolic syndrome NHANES WQS |
| title | Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular‐Kidney‐Metabolic Syndrome Among the General Adult Population |
| title_full | Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular‐Kidney‐Metabolic Syndrome Among the General Adult Population |
| title_fullStr | Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular‐Kidney‐Metabolic Syndrome Among the General Adult Population |
| title_full_unstemmed | Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular‐Kidney‐Metabolic Syndrome Among the General Adult Population |
| title_short | Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular‐Kidney‐Metabolic Syndrome Among the General Adult Population |
| title_sort | inverse relationship between serum carotenoid levels and cardiovascular kidney metabolic syndrome among the general adult population |
| topic | cardiovascular disease carotenoids kidney disease metabolic syndrome NHANES WQS |
| url | https://doi.org/10.1111/1753-0407.70046 |
| work_keys_str_mv | AT menglichen inverserelationshipbetweenserumcarotenoidlevelsandcardiovascularkidneymetabolicsyndromeamongthegeneraladultpopulation AT shuyuecai inverserelationshipbetweenserumcarotenoidlevelsandcardiovascularkidneymetabolicsyndromeamongthegeneraladultpopulation AT qinfengjia inverserelationshipbetweenserumcarotenoidlevelsandcardiovascularkidneymetabolicsyndromeamongthegeneraladultpopulation AT yifangsuo inverserelationshipbetweenserumcarotenoidlevelsandcardiovascularkidneymetabolicsyndromeamongthegeneraladultpopulation AT yuantang inverserelationshipbetweenserumcarotenoidlevelsandcardiovascularkidneymetabolicsyndromeamongthegeneraladultpopulation AT yanpingshi inverserelationshipbetweenserumcarotenoidlevelsandcardiovascularkidneymetabolicsyndromeamongthegeneraladultpopulation AT xuzhu inverserelationshipbetweenserumcarotenoidlevelsandcardiovascularkidneymetabolicsyndromeamongthegeneraladultpopulation AT haifengzhang inverserelationshipbetweenserumcarotenoidlevelsandcardiovascularkidneymetabolicsyndromeamongthegeneraladultpopulation |