A homeostatic model of IκB metabolism to control constitutive NF‐κB activity
Abstract Cellular signal transduction pathways are usually studied following administration of an external stimulus. However, disease‐associated aberrant activity of the pathway is often due to misregulation of the equilibrium state. The transcription factor NF‐κB is typically described as being hel...
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| Main Authors: | Ellen L O'Dea, Derren Barken, Raechel Q Peralta, Kim T Tran, Shannon L Werner, Jeffrey D Kearns, Andre Levchenko, Alexander Hoffmann |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2007-05-01
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| Series: | Molecular Systems Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/msb4100148 |
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