Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome
A positive surgical margin at prostatectomy is defined as tumor cells touching the inked edge of the specimen. This finding is reported in 8.8% to 42% of cases (median about 20%) in various studies. It is one of the main determinants of eventual biochemical (PSA) failure, generally associated with...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/673021 |
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| author | Kenneth A. Iczkowski M. Scott Lucia |
| author_facet | Kenneth A. Iczkowski M. Scott Lucia |
| author_sort | Kenneth A. Iczkowski |
| collection | DOAJ |
| description | A positive surgical margin at prostatectomy is defined as tumor cells touching the inked edge of the specimen. This finding is reported in 8.8% to 42% of cases (median about 20%) in various studies. It is one of the main determinants of eventual biochemical (PSA) failure, generally associated with a doubled or tripled risk of failure. The effect of a positive margin on outcome can be modified by stage or grade and the length, number and location of positive margins, as well as by technical operative approach and duration of operator experience. This paper tabulates data from the past decade of studies on margin status. |
| format | Article |
| id | doaj-art-9dcb00ad1a3c43b9a290c151d407bc32 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-9dcb00ad1a3c43b9a290c151d407bc322025-02-03T06:00:46ZengWileyProstate Cancer2090-31112090-312X2011-01-01201110.1155/2011/673021673021Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient OutcomeKenneth A. Iczkowski0M. Scott Lucia1Department of Pathology, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USADepartment of Pathology, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USAA positive surgical margin at prostatectomy is defined as tumor cells touching the inked edge of the specimen. This finding is reported in 8.8% to 42% of cases (median about 20%) in various studies. It is one of the main determinants of eventual biochemical (PSA) failure, generally associated with a doubled or tripled risk of failure. The effect of a positive margin on outcome can be modified by stage or grade and the length, number and location of positive margins, as well as by technical operative approach and duration of operator experience. This paper tabulates data from the past decade of studies on margin status.http://dx.doi.org/10.1155/2011/673021 |
| spellingShingle | Kenneth A. Iczkowski M. Scott Lucia Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome Prostate Cancer |
| title | Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome |
| title_full | Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome |
| title_fullStr | Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome |
| title_full_unstemmed | Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome |
| title_short | Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome |
| title_sort | frequency of positive surgical margin at prostatectomy and its effect on patient outcome |
| url | http://dx.doi.org/10.1155/2011/673021 |
| work_keys_str_mv | AT kennethaiczkowski frequencyofpositivesurgicalmarginatprostatectomyanditseffectonpatientoutcome AT mscottlucia frequencyofpositivesurgicalmarginatprostatectomyanditseffectonpatientoutcome |