Altered Cerebro-Cerebellar Functional Connectivity Associated With Working Memory Decline After Sleep Deprivation
Background: It has been demonstrated that the cerebellum plays a critical role not only in motor function but also in cognitive function. Numerous studies have revealed that acute sleep deprivation (SD) alters the functional connectivity (FC) in the cerebral cortex associated with...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2025-06-01
|
| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/24/6/10.31083/JIN36443 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849415528993521664 |
|---|---|
| author | Ziyao Wu Sitong Feng Sisi Zheng Linrui Dong Hongxiao Jia Yanzhe Ning |
| author_facet | Ziyao Wu Sitong Feng Sisi Zheng Linrui Dong Hongxiao Jia Yanzhe Ning |
| author_sort | Ziyao Wu |
| collection | DOAJ |
| description | Background: It has been demonstrated that the cerebellum plays a critical role not only in motor function but also in cognitive function. Numerous studies have revealed that acute sleep deprivation (SD) alters the functional connectivity (FC) in the cerebral cortex associated with declining working memory (WM). However, the relationship between the altered cerebro-cerebellar FC and white matter damage following acute sleep deprivation remains elusive. Methods: In this study, 26 healthy participants with regular sleep conducted an n-back task and had resting-state functional magnetic resonance imaging (fMRI) scans before and after 24 h of SD. The FC between the cerebrum and cerebellum and its relationship with WM function were analyzed in recruited participants. Results: Our results showed a significantly longer RT for the 1-back and 2-back tasks and lower accuracy of the 2-back task after SD. We found a marked reduction in FC between ten pairs of regions in the cerebellum and cerebrum after SD. Furthermore, a decline in WM performance was positively correlated with the changed FC between the left precentral gyrus and the right lobule X of the cerebellum. Conclusion: Our findings indicate that the impaired FC between the cerebellum and cortical areas may contribute to the decline in WM after acute SD. Clinical Trial Registration: No: ChiCTR2000039858. Registered 12 November, 2020, https://www.chictr.org.cn/showproj.html?proj=63916. |
| format | Article |
| id | doaj-art-9dc81fd0bdd44a918f9a51d504e63bb8 |
| institution | Kabale University |
| issn | 0219-6352 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj-art-9dc81fd0bdd44a918f9a51d504e63bb82025-08-20T03:33:31ZengIMR PressJournal of Integrative Neuroscience0219-63522025-06-012463644310.31083/JIN36443S0219-6352(25)00959-3Altered Cerebro-Cerebellar Functional Connectivity Associated With Working Memory Decline After Sleep DeprivationZiyao Wu0Sitong Feng1Sisi Zheng2Linrui Dong3Hongxiao Jia4Yanzhe Ning5Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, ChinaBackground: It has been demonstrated that the cerebellum plays a critical role not only in motor function but also in cognitive function. Numerous studies have revealed that acute sleep deprivation (SD) alters the functional connectivity (FC) in the cerebral cortex associated with declining working memory (WM). However, the relationship between the altered cerebro-cerebellar FC and white matter damage following acute sleep deprivation remains elusive. Methods: In this study, 26 healthy participants with regular sleep conducted an n-back task and had resting-state functional magnetic resonance imaging (fMRI) scans before and after 24 h of SD. The FC between the cerebrum and cerebellum and its relationship with WM function were analyzed in recruited participants. Results: Our results showed a significantly longer RT for the 1-back and 2-back tasks and lower accuracy of the 2-back task after SD. We found a marked reduction in FC between ten pairs of regions in the cerebellum and cerebrum after SD. Furthermore, a decline in WM performance was positively correlated with the changed FC between the left precentral gyrus and the right lobule X of the cerebellum. Conclusion: Our findings indicate that the impaired FC between the cerebellum and cortical areas may contribute to the decline in WM after acute SD. Clinical Trial Registration: No: ChiCTR2000039858. Registered 12 November, 2020, https://www.chictr.org.cn/showproj.html?proj=63916.https://www.imrpress.com/journal/JIN/24/6/10.31083/JIN36443sleep deprivationthe cerebrumthe cerebellumfunctional connectivityworking memory |
| spellingShingle | Ziyao Wu Sitong Feng Sisi Zheng Linrui Dong Hongxiao Jia Yanzhe Ning Altered Cerebro-Cerebellar Functional Connectivity Associated With Working Memory Decline After Sleep Deprivation Journal of Integrative Neuroscience sleep deprivation the cerebrum the cerebellum functional connectivity working memory |
| title | Altered Cerebro-Cerebellar Functional Connectivity Associated With Working Memory Decline After Sleep Deprivation |
| title_full | Altered Cerebro-Cerebellar Functional Connectivity Associated With Working Memory Decline After Sleep Deprivation |
| title_fullStr | Altered Cerebro-Cerebellar Functional Connectivity Associated With Working Memory Decline After Sleep Deprivation |
| title_full_unstemmed | Altered Cerebro-Cerebellar Functional Connectivity Associated With Working Memory Decline After Sleep Deprivation |
| title_short | Altered Cerebro-Cerebellar Functional Connectivity Associated With Working Memory Decline After Sleep Deprivation |
| title_sort | altered cerebro cerebellar functional connectivity associated with working memory decline after sleep deprivation |
| topic | sleep deprivation the cerebrum the cerebellum functional connectivity working memory |
| url | https://www.imrpress.com/journal/JIN/24/6/10.31083/JIN36443 |
| work_keys_str_mv | AT ziyaowu alteredcerebrocerebellarfunctionalconnectivityassociatedwithworkingmemorydeclineaftersleepdeprivation AT sitongfeng alteredcerebrocerebellarfunctionalconnectivityassociatedwithworkingmemorydeclineaftersleepdeprivation AT sisizheng alteredcerebrocerebellarfunctionalconnectivityassociatedwithworkingmemorydeclineaftersleepdeprivation AT linruidong alteredcerebrocerebellarfunctionalconnectivityassociatedwithworkingmemorydeclineaftersleepdeprivation AT hongxiaojia alteredcerebrocerebellarfunctionalconnectivityassociatedwithworkingmemorydeclineaftersleepdeprivation AT yanzhening alteredcerebrocerebellarfunctionalconnectivityassociatedwithworkingmemorydeclineaftersleepdeprivation |