Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China
Objective. This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. Then, we analyzed the effect of MTHFR 677C > T polymorphism on the association between the above miRNA and H-type hypertension. Method. In this...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2022/4632087 |
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| author | Xin He RuLin Ma Yu Li Haixia Wang YiZhong Yan YiDan Mao ShengYu Liao XueYing Sun ShuXia Guo Heng Guo |
| author_facet | Xin He RuLin Ma Yu Li Haixia Wang YiZhong Yan YiDan Mao ShengYu Liao XueYing Sun ShuXia Guo Heng Guo |
| author_sort | Xin He |
| collection | DOAJ |
| description | Objective. This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. Then, we analyzed the effect of MTHFR 677C > T polymorphism on the association between the above miRNA and H-type hypertension. Method. In this study, the expression of miR-21, miR-29, and miR-199 was quantitatively measured in 120 serum samples and then stratified according to the C677T polymorphism to analyze the relationship between target miRNAs and HHcy. Results. The expression of miR-21/-29 in the hypertension group was higher than the normal group (P<0.001). And the expression of miR-199 was higher in the hcy group than in the normal group (P<0.001). In the CC and CT genotypes of MTHFR 677C > T, the expression of miR-21 was lower in the HHcy patients than in the normal individuals (P=0.005 and P=0.001) and miR-199 was significantly higher in the HHcy patients than in the normal ones (P=0.002 and P=0.048). No such difference was found in the TT genotype. Logistic regression analysis showed that after adjusting for sex, age, BMI, systolic blood pressure, diastolic blood pressure, and MTHFRC677 T gene polymorphism, miR-21 was negatively correlated with hcy (OR = 0.222, 95% CI (0.101–0.485), P<0.001) and miR-199 was positively correlated with hcy (OR = 1.823,95%CI (1.272∼2.614), P=0.001). Conclusion. miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia. And these three miRNAs may serve as biomarkers to provide clues to the potential pathogenesis of H-type hypertension. |
| format | Article |
| id | doaj-art-9dbd73ee5a77460bae20307e0603bad8 |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-9dbd73ee5a77460bae20307e0603bad82025-02-03T01:00:42ZengWileyInternational Journal of Hypertension2090-03922022-01-01202210.1155/2022/4632087Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, ChinaXin He0RuLin Ma1Yu Li2Haixia Wang3YiZhong Yan4YiDan Mao5ShengYu Liao6XueYing Sun7ShuXia Guo8Heng Guo9Department of Public HealthDepartment of Public HealthDepartment of Public HealthDepartment of Public HealthDepartment of Public HealthDepartment of Public HealthDepartment of Public HealthDepartment of Public HealthDepartment of Public HealthDepartment of Public HealthObjective. This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. Then, we analyzed the effect of MTHFR 677C > T polymorphism on the association between the above miRNA and H-type hypertension. Method. In this study, the expression of miR-21, miR-29, and miR-199 was quantitatively measured in 120 serum samples and then stratified according to the C677T polymorphism to analyze the relationship between target miRNAs and HHcy. Results. The expression of miR-21/-29 in the hypertension group was higher than the normal group (P<0.001). And the expression of miR-199 was higher in the hcy group than in the normal group (P<0.001). In the CC and CT genotypes of MTHFR 677C > T, the expression of miR-21 was lower in the HHcy patients than in the normal individuals (P=0.005 and P=0.001) and miR-199 was significantly higher in the HHcy patients than in the normal ones (P=0.002 and P=0.048). No such difference was found in the TT genotype. Logistic regression analysis showed that after adjusting for sex, age, BMI, systolic blood pressure, diastolic blood pressure, and MTHFRC677 T gene polymorphism, miR-21 was negatively correlated with hcy (OR = 0.222, 95% CI (0.101–0.485), P<0.001) and miR-199 was positively correlated with hcy (OR = 1.823,95%CI (1.272∼2.614), P=0.001). Conclusion. miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia. And these three miRNAs may serve as biomarkers to provide clues to the potential pathogenesis of H-type hypertension.http://dx.doi.org/10.1155/2022/4632087 |
| spellingShingle | Xin He RuLin Ma Yu Li Haixia Wang YiZhong Yan YiDan Mao ShengYu Liao XueYing Sun ShuXia Guo Heng Guo Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China International Journal of Hypertension |
| title | Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China |
| title_full | Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China |
| title_fullStr | Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China |
| title_full_unstemmed | Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China |
| title_short | Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China |
| title_sort | association of h type hypertension with mir 21 mir 29 and mir 199 in kazahks of xinjiang china |
| url | http://dx.doi.org/10.1155/2022/4632087 |
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