Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing
The high mortality risk of burn infected wounds has dictated the clinical need for the development of new biomaterials that can regulate multiple aspects of the healing process in a high-quality manner. Although nanozymes have made progress in inflammation modulation and antibacterial management, th...
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000808 |
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| author | Wei Duan Yue Gao Ruru Xu Sheng Huang Xueqian Xia Jingwen Zhao Longhuan Zeng Qiaolin Wei Jia-Wei Shen Jianmin Wu Yongke Zheng |
| author_facet | Wei Duan Yue Gao Ruru Xu Sheng Huang Xueqian Xia Jingwen Zhao Longhuan Zeng Qiaolin Wei Jia-Wei Shen Jianmin Wu Yongke Zheng |
| author_sort | Wei Duan |
| collection | DOAJ |
| description | The high mortality risk of burn infected wounds has dictated the clinical need for the development of new biomaterials that can regulate multiple aspects of the healing process in a high-quality manner. Although nanozymes have made progress in inflammation modulation and antibacterial management, they often lack the ability in pro-angiogenesis, which greatly limits their functional application in the synergistic treatment of burn infected wounds. In this study, a smart pro-angiogenic nanozyme is simply and efficiently synthesized by in situ reduction of Pt precursors on porous silicon (PSi) nanocarriers. Owing to the hybridization of Pt, the Pt-decorated PSi (Pt@PSi) nanocomposites exhibit excellent near-infrared (NIR) photothermal activity and peroxidase-like catalytic activity, which can be used for co-efficient antibacterial treatment. After exposure to 808 nm NIR laser, Pt@PSi-based photothermal and nano-catalytic combined therapy can achieve more than 95 % bacterial inhibition in vitro. More importantly, under the stimulation of NIR laser and nanozyme, the smart Pt@PSi nanocomposites can efficiently release bioactive inorganic Si ions from the PSi skeleton, which can efficiently promote endothelial cell migration, tube formation, and angiogenesis. Furthermore, In vivo animal studies have demonstrated that Pt@PSi-based combination therapy can significantly accelerate the healing of infected burn infections by inhibiting bacterial growth, scavenging reactive oxygen species, and promoting angiogenesis with a favorable biosafety. Overall, the dual-driven pro-angiogenic nanozyme based on PSi expands the functional application of nanozyme, providing a novel combined strategy for efficient care of difficult-to-heal burn infected wounds. |
| format | Article |
| id | doaj-art-9db98015a7d14a5b8bbfd943286068b9 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-9db98015a7d14a5b8bbfd943286068b92025-01-29T05:01:40ZengElsevierMaterials Today Bio2590-00642025-04-0131101522Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healingWei Duan0Yue Gao1Ruru Xu2Sheng Huang3Xueqian Xia4Jingwen Zhao5Longhuan Zeng6Qiaolin Wei7Jia-Wei Shen8Jianmin Wu9Yongke Zheng10School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, PR China; Lab of Nanomedicine and Omic-based Diagnostics, Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310058, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China; State Key Laboratory of Silicon and Advanced Semiconductor Materials, Zhejiang University, Hangzhou, 310027, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, PR ChinaLab of Nanomedicine and Omic-based Diagnostics, Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310058, PR ChinaDepartment of Rehabilitation, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310006, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China; State Key Laboratory of Silicon and Advanced Semiconductor Materials, Zhejiang University, Hangzhou, 310027, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China; Corresponding author. School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, PR China.Lab of Nanomedicine and Omic-based Diagnostics, Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310058, PR China; Corresponding author.Department of Rehabilitation, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310006, PR China; Corresponding author.The high mortality risk of burn infected wounds has dictated the clinical need for the development of new biomaterials that can regulate multiple aspects of the healing process in a high-quality manner. Although nanozymes have made progress in inflammation modulation and antibacterial management, they often lack the ability in pro-angiogenesis, which greatly limits their functional application in the synergistic treatment of burn infected wounds. In this study, a smart pro-angiogenic nanozyme is simply and efficiently synthesized by in situ reduction of Pt precursors on porous silicon (PSi) nanocarriers. Owing to the hybridization of Pt, the Pt-decorated PSi (Pt@PSi) nanocomposites exhibit excellent near-infrared (NIR) photothermal activity and peroxidase-like catalytic activity, which can be used for co-efficient antibacterial treatment. After exposure to 808 nm NIR laser, Pt@PSi-based photothermal and nano-catalytic combined therapy can achieve more than 95 % bacterial inhibition in vitro. More importantly, under the stimulation of NIR laser and nanozyme, the smart Pt@PSi nanocomposites can efficiently release bioactive inorganic Si ions from the PSi skeleton, which can efficiently promote endothelial cell migration, tube formation, and angiogenesis. Furthermore, In vivo animal studies have demonstrated that Pt@PSi-based combination therapy can significantly accelerate the healing of infected burn infections by inhibiting bacterial growth, scavenging reactive oxygen species, and promoting angiogenesis with a favorable biosafety. Overall, the dual-driven pro-angiogenic nanozyme based on PSi expands the functional application of nanozyme, providing a novel combined strategy for efficient care of difficult-to-heal burn infected wounds.http://www.sciencedirect.com/science/article/pii/S2590006425000808Burn infected woundsNanozymePorous siliconAngiogenesisPhotothermal therapy |
| spellingShingle | Wei Duan Yue Gao Ruru Xu Sheng Huang Xueqian Xia Jingwen Zhao Longhuan Zeng Qiaolin Wei Jia-Wei Shen Jianmin Wu Yongke Zheng Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing Materials Today Bio Burn infected wounds Nanozyme Porous silicon Angiogenesis Photothermal therapy |
| title | Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing |
| title_full | Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing |
| title_fullStr | Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing |
| title_full_unstemmed | Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing |
| title_short | Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing |
| title_sort | engineering dual driven pro angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing |
| topic | Burn infected wounds Nanozyme Porous silicon Angiogenesis Photothermal therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000808 |
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