Influence of total low dose fractionated radiation on growth and metastasis of mice Lewis lung carcinoma
Effects of prolonged fractionated ionized radiation in low doses on the growth and metastasis intensity of mice Lewis lung carcinoma (LLC) are studied. On the background of tumor growth, stimulation induced by irradiation in the selected mode of dose fractionation inhibition of spontaneous dissemina...
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| Format: | Article |
| Language: | English |
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Institute for Nuclear Research, National Academy of Sciences of Ukraine
2015-07-01
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| Series: | Ядерна фізика та енергетика |
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| Online Access: | http://jnpae.kinr.kiev.ua/16.2/html/16.2.0164.html |
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| author | N. M. Ryabchenko O. B. Ganzha M. O. Druzhyna |
| author_facet | N. M. Ryabchenko O. B. Ganzha M. O. Druzhyna |
| author_sort | N. M. Ryabchenko |
| collection | DOAJ |
| description | Effects of prolonged fractionated ionized radiation in low doses on the growth and metastasis intensity of mice Lewis lung carcinoma (LLC) are studied. On the background of tumor growth, stimulation induced by irradiation in the selected mode of dose fractionation inhibition of spontaneous dissemination of tumor cells into lungs is observed. On the 23-rd day after cell inoculation metastases incidence in irradiated animals was 25 % lower; the number and size of lung metastases decreased by 1.6 and 1.7 times. In the remote terms of tumor growth inhibition of functional activity of macrophages – central effectors of non-specific anti-tumor immunity was revealed. |
| format | Article |
| id | doaj-art-9db0dadc4e524c848e825b33a0a5c6ee |
| institution | DOAJ |
| issn | 1818-331X 2074-0565 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | Institute for Nuclear Research, National Academy of Sciences of Ukraine |
| record_format | Article |
| series | Ядерна фізика та енергетика |
| spelling | doaj-art-9db0dadc4e524c848e825b33a0a5c6ee2025-08-20T03:19:56ZengInstitute for Nuclear Research, National Academy of Sciences of UkraineЯдерна фізика та енергетика1818-331X2074-05652015-07-01162164168Influence of total low dose fractionated radiation on growth and metastasis of mice Lewis lung carcinomaN. M. Ryabchenko0O. B. Ganzha1M. O. Druzhyna2Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine Effects of prolonged fractionated ionized radiation in low doses on the growth and metastasis intensity of mice Lewis lung carcinoma (LLC) are studied. On the background of tumor growth, stimulation induced by irradiation in the selected mode of dose fractionation inhibition of spontaneous dissemination of tumor cells into lungs is observed. On the 23-rd day after cell inoculation metastases incidence in irradiated animals was 25 % lower; the number and size of lung metastases decreased by 1.6 and 1.7 times. In the remote terms of tumor growth inhibition of functional activity of macrophages – central effectors of non-specific anti-tumor immunity was revealed.http://jnpae.kinr.kiev.ua/16.2/html/16.2.0164.htmllow dose ionizing radiationmice Lewis lung carcinomanonspecific antitumor immune response |
| spellingShingle | N. M. Ryabchenko O. B. Ganzha M. O. Druzhyna Influence of total low dose fractionated radiation on growth and metastasis of mice Lewis lung carcinoma Ядерна фізика та енергетика low dose ionizing radiation mice Lewis lung carcinoma nonspecific antitumor immune response |
| title | Influence of total low dose fractionated radiation on growth and metastasis of mice Lewis lung carcinoma |
| title_full | Influence of total low dose fractionated radiation on growth and metastasis of mice Lewis lung carcinoma |
| title_fullStr | Influence of total low dose fractionated radiation on growth and metastasis of mice Lewis lung carcinoma |
| title_full_unstemmed | Influence of total low dose fractionated radiation on growth and metastasis of mice Lewis lung carcinoma |
| title_short | Influence of total low dose fractionated radiation on growth and metastasis of mice Lewis lung carcinoma |
| title_sort | influence of total low dose fractionated radiation on growth and metastasis of mice lewis lung carcinoma |
| topic | low dose ionizing radiation mice Lewis lung carcinoma nonspecific antitumor immune response |
| url | http://jnpae.kinr.kiev.ua/16.2/html/16.2.0164.html |
| work_keys_str_mv | AT nmryabchenko influenceoftotallowdosefractionatedradiationongrowthandmetastasisofmicelewislungcarcinoma AT obganzha influenceoftotallowdosefractionatedradiationongrowthandmetastasisofmicelewislungcarcinoma AT modruzhyna influenceoftotallowdosefractionatedradiationongrowthandmetastasisofmicelewislungcarcinoma |