Prognostic significance and therapeutic outcome prediction through serum miR-21 and miR-145 in ovarian cancer
Abstract This study investigated the diagnostic value of serum microRNA-21 (miR-21) and miR-145 in assessing the treatment response and prognosis of ovarian cancer patients. A total of 139 patients enrolled in this study were categorized based on their chemotherapy outcomes into three groups: partia...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2025-04-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652025000200603&lng=en&tlng=en |
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| _version_ | 1849710479268642816 |
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| author | SHULIN ZHONG WEIQUAN WU YUZHEN LIANG ZHIXI WU |
| author_facet | SHULIN ZHONG WEIQUAN WU YUZHEN LIANG ZHIXI WU |
| author_sort | SHULIN ZHONG |
| collection | DOAJ |
| description | Abstract This study investigated the diagnostic value of serum microRNA-21 (miR-21) and miR-145 in assessing the treatment response and prognosis of ovarian cancer patients. A total of 139 patients enrolled in this study were categorized based on their chemotherapy outcomes into three groups: partial response, stable disease, and disease progression. Significant differences in serum levels of miR-21 and miR-145 among these groups were observed. Specifically, elevated miR-21 and reduced miR-145 levels were associated with worse treatment outcomes and poorer prognoses. Multivariate logistic regression analysis identified miR-21 and miR-145, along with age, tumor stage, and lymph node metastasis, as independent predictors of patient outcomes. The receiver operating curve (ROC) analysis indicated that the combination of miR-21 and miR-145 provided higher accuracy in predicting patient prognosis compared to each biomarker alone. The findings suggest that miR-21 and miR-145 can be effective supplementary tools for evaluating treatment effectiveness and prognostic assessments in ovarian cancer patients. |
| format | Article |
| id | doaj-art-9dafadfe7529402cb94bd2a06a8a8b23 |
| institution | DOAJ |
| issn | 1678-2690 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj-art-9dafadfe7529402cb94bd2a06a8a8b232025-08-20T03:14:53ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902025-04-0197210.1590/0001-3765202520240565Prognostic significance and therapeutic outcome prediction through serum miR-21 and miR-145 in ovarian cancerSHULIN ZHONGhttps://orcid.org/0009-0002-3225-5254WEIQUAN WUhttps://orcid.org/0009-0009-7568-2089YUZHEN LIANGhttps://orcid.org/0009-0007-6584-6778ZHIXI WUhttps://orcid.org/0009-0006-7514-7594Abstract This study investigated the diagnostic value of serum microRNA-21 (miR-21) and miR-145 in assessing the treatment response and prognosis of ovarian cancer patients. A total of 139 patients enrolled in this study were categorized based on their chemotherapy outcomes into three groups: partial response, stable disease, and disease progression. Significant differences in serum levels of miR-21 and miR-145 among these groups were observed. Specifically, elevated miR-21 and reduced miR-145 levels were associated with worse treatment outcomes and poorer prognoses. Multivariate logistic regression analysis identified miR-21 and miR-145, along with age, tumor stage, and lymph node metastasis, as independent predictors of patient outcomes. The receiver operating curve (ROC) analysis indicated that the combination of miR-21 and miR-145 provided higher accuracy in predicting patient prognosis compared to each biomarker alone. The findings suggest that miR-21 and miR-145 can be effective supplementary tools for evaluating treatment effectiveness and prognostic assessments in ovarian cancer patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652025000200603&lng=en&tlng=enmiR-21miR-145ovarian cancerchemotherapyprognostic assessment |
| spellingShingle | SHULIN ZHONG WEIQUAN WU YUZHEN LIANG ZHIXI WU Prognostic significance and therapeutic outcome prediction through serum miR-21 and miR-145 in ovarian cancer Anais da Academia Brasileira de Ciências miR-21 miR-145 ovarian cancer chemotherapy prognostic assessment |
| title | Prognostic significance and therapeutic outcome prediction through serum miR-21 and miR-145 in ovarian cancer |
| title_full | Prognostic significance and therapeutic outcome prediction through serum miR-21 and miR-145 in ovarian cancer |
| title_fullStr | Prognostic significance and therapeutic outcome prediction through serum miR-21 and miR-145 in ovarian cancer |
| title_full_unstemmed | Prognostic significance and therapeutic outcome prediction through serum miR-21 and miR-145 in ovarian cancer |
| title_short | Prognostic significance and therapeutic outcome prediction through serum miR-21 and miR-145 in ovarian cancer |
| title_sort | prognostic significance and therapeutic outcome prediction through serum mir 21 and mir 145 in ovarian cancer |
| topic | miR-21 miR-145 ovarian cancer chemotherapy prognostic assessment |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652025000200603&lng=en&tlng=en |
| work_keys_str_mv | AT shulinzhong prognosticsignificanceandtherapeuticoutcomepredictionthroughserummir21andmir145inovariancancer AT weiquanwu prognosticsignificanceandtherapeuticoutcomepredictionthroughserummir21andmir145inovariancancer AT yuzhenliang prognosticsignificanceandtherapeuticoutcomepredictionthroughserummir21andmir145inovariancancer AT zhixiwu prognosticsignificanceandtherapeuticoutcomepredictionthroughserummir21andmir145inovariancancer |