Influence of Marsilea crenata and Alpinia purpurata Ethanol Extract on MDA and SOD Testicular Cells of Hyperglycemia Mice
Hyperglycemia can induce testicular damage that leads to male infertility. Herbal plants, such as Marsilea crenata and Alpinia purpurata, are used for antioxidant defense systems to repair reproductive disorders due to hyperglycemia. This study aims to evaluate the effect of M. crenata and A. purpur...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Brawijaya
2023-10-01
|
| Series: | Journal of Experimental Life Science |
| Subjects: | |
| Online Access: | https://jels.ub.ac.id/index.php/jels/article/view/539 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850281373054533632 |
|---|---|
| author | Febriane Eka Damayanti Sri Rahayu Sri Widyarti |
| author_facet | Febriane Eka Damayanti Sri Rahayu Sri Widyarti |
| author_sort | Febriane Eka Damayanti |
| collection | DOAJ |
| description | Hyperglycemia can induce testicular damage that leads to male infertility. Herbal plants, such as Marsilea crenata and Alpinia purpurata, are used for antioxidant defense systems to repair reproductive disorders due to hyperglycemia. This study aims to evaluate the effect of M. crenata and A. purpurata ethanol extracts on MDA and SOD testes of hyperglycemia mice. This study used a completely randomized design with seven treatment groups (n=4), namely N (control group), H (hyperglycemia mice), Met (hyperglycemia mice given metformin), D1 (0. 09 mg.g-1 M. crenata), D2 (0.2 mg.g-1 A. purpurata), D3 (0.09 mg.g-1 M. crenata + 0.2 mg.g-1 A. purpurata), and D4 (0.09 mg.g-1 M. crenata + 0.4 mg.g-1 A. purpurata). The extracts were administered orally for 17 days. Analysis of testicular MDA and SOD levels was performed by flow cytometry. Data analysis was performed with a one-way ANOVA test and continued with the Tukey test. The results showed that the D4 treatment group, compared to D3, D2, D1, Met, H, and N, showed a better decrease in MDA levels (4.47%) and an increase in SOD levels in the D4 group (4.77%). The research concludes that the combination of 0.09 mg.g-1 M. crenata and 0.4 mg.g-1 A. purpurata was an optimal dose to decrease MDA levels and increase SOD levels in the testes of hyperglycemic mice. |
| format | Article |
| id | doaj-art-9dacc1da34a3469b9f539d95c23cdd06 |
| institution | OA Journals |
| issn | 2087-2852 2338-1655 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Journal of Experimental Life Science |
| spelling | doaj-art-9dacc1da34a3469b9f539d95c23cdd062025-08-20T01:48:20ZengUniversity of BrawijayaJournal of Experimental Life Science2087-28522338-16552023-10-01133159165https://doi.org/10.21776/ub.jels.2023.013.03.04Influence of Marsilea crenata and Alpinia purpurata Ethanol Extract on MDA and SOD Testicular Cells of Hyperglycemia MiceFebriane Eka Damayanti0Sri Rahayu1Sri Widyarti2Universitas Brawijaya, Malang, IndonesiaUniversitas Brawijaya, Malang, IndonesiaUniversitas Brawijaya, Malang, IndonesiaHyperglycemia can induce testicular damage that leads to male infertility. Herbal plants, such as Marsilea crenata and Alpinia purpurata, are used for antioxidant defense systems to repair reproductive disorders due to hyperglycemia. This study aims to evaluate the effect of M. crenata and A. purpurata ethanol extracts on MDA and SOD testes of hyperglycemia mice. This study used a completely randomized design with seven treatment groups (n=4), namely N (control group), H (hyperglycemia mice), Met (hyperglycemia mice given metformin), D1 (0. 09 mg.g-1 M. crenata), D2 (0.2 mg.g-1 A. purpurata), D3 (0.09 mg.g-1 M. crenata + 0.2 mg.g-1 A. purpurata), and D4 (0.09 mg.g-1 M. crenata + 0.4 mg.g-1 A. purpurata). The extracts were administered orally for 17 days. Analysis of testicular MDA and SOD levels was performed by flow cytometry. Data analysis was performed with a one-way ANOVA test and continued with the Tukey test. The results showed that the D4 treatment group, compared to D3, D2, D1, Met, H, and N, showed a better decrease in MDA levels (4.47%) and an increase in SOD levels in the D4 group (4.77%). The research concludes that the combination of 0.09 mg.g-1 M. crenata and 0.4 mg.g-1 A. purpurata was an optimal dose to decrease MDA levels and increase SOD levels in the testes of hyperglycemic mice.https://jels.ub.ac.id/index.php/jels/article/view/539alpinia purpuratamarsilea crenatamdasodtestes. |
| spellingShingle | Febriane Eka Damayanti Sri Rahayu Sri Widyarti Influence of Marsilea crenata and Alpinia purpurata Ethanol Extract on MDA and SOD Testicular Cells of Hyperglycemia Mice Journal of Experimental Life Science alpinia purpurata marsilea crenata mda sod testes. |
| title | Influence of Marsilea crenata and Alpinia purpurata Ethanol Extract on MDA and SOD Testicular Cells of Hyperglycemia Mice |
| title_full | Influence of Marsilea crenata and Alpinia purpurata Ethanol Extract on MDA and SOD Testicular Cells of Hyperglycemia Mice |
| title_fullStr | Influence of Marsilea crenata and Alpinia purpurata Ethanol Extract on MDA and SOD Testicular Cells of Hyperglycemia Mice |
| title_full_unstemmed | Influence of Marsilea crenata and Alpinia purpurata Ethanol Extract on MDA and SOD Testicular Cells of Hyperglycemia Mice |
| title_short | Influence of Marsilea crenata and Alpinia purpurata Ethanol Extract on MDA and SOD Testicular Cells of Hyperglycemia Mice |
| title_sort | influence of marsilea crenata and alpinia purpurata ethanol extract on mda and sod testicular cells of hyperglycemia mice |
| topic | alpinia purpurata marsilea crenata mda sod testes. |
| url | https://jels.ub.ac.id/index.php/jels/article/view/539 |
| work_keys_str_mv | AT febrianeekadamayanti influenceofmarsileacrenataandalpiniapurpurataethanolextractonmdaandsodtesticularcellsofhyperglycemiamice AT srirahayu influenceofmarsileacrenataandalpiniapurpurataethanolextractonmdaandsodtesticularcellsofhyperglycemiamice AT sriwidyarti influenceofmarsileacrenataandalpiniapurpurataethanolextractonmdaandsodtesticularcellsofhyperglycemiamice |