Bacillus subtilis surface display technology: applications in bioprocessing and sustainable manufacturing
Abstract The growing demand for sustainable and eco-friendly alternatives in bioprocessing, healthcare, and manufacturing has stimulated significant interest in Bacillus subtilis surface display technology. This innovative platform, leveraging both spore and vegetative cell forms, provides exception...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Biotechnology for Biofuels and Bioproducts |
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| Online Access: | https://doi.org/10.1186/s13068-025-02635-4 |
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| author | Howra Bahrulolum Gholamreza Ahmadian |
| author_facet | Howra Bahrulolum Gholamreza Ahmadian |
| author_sort | Howra Bahrulolum |
| collection | DOAJ |
| description | Abstract The growing demand for sustainable and eco-friendly alternatives in bioprocessing, healthcare, and manufacturing has stimulated significant interest in Bacillus subtilis surface display technology. This innovative platform, leveraging both spore and vegetative cell forms, provides exceptional versatility for a wide spectrum of applications, spanning from green technologies to advanced biomedical innovations. The robustness of spores and the metabolic activity of vegetative cells enable efficient enzyme immobilization, biocatalysis, and biosensor development, facilitating bioremediation, pollutant degradation, and renewable energy generation. Additionally, B. subtilis surface display systems have demonstrated remarkable potential in vaccine development and drug delivery, offering a cost-effective, scalable, and environmentally sustainable alternative to traditional methods. These systems can effectively present antigens or therapeutic molecules, enabling targeted drug delivery and robust immune responses. This review explores recent advancements, challenges, and opportunities in harnessing B. subtilis surface display technology for sustainable biomanufacturing, green innovations, and transformative biomedical applications, emphasizing its role in addressing pressing global challenges in environmental sustainability and healthcare. |
| format | Article |
| id | doaj-art-9da7fcb87fa14faa8693d1e60aae2220 |
| institution | DOAJ |
| issn | 2731-3654 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Biotechnology for Biofuels and Bioproducts |
| spelling | doaj-art-9da7fcb87fa14faa8693d1e60aae22202025-08-20T02:56:11ZengBMCBiotechnology for Biofuels and Bioproducts2731-36542025-03-0118112210.1186/s13068-025-02635-4Bacillus subtilis surface display technology: applications in bioprocessing and sustainable manufacturingHowra Bahrulolum0Gholamreza Ahmadian1Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB)Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB)Abstract The growing demand for sustainable and eco-friendly alternatives in bioprocessing, healthcare, and manufacturing has stimulated significant interest in Bacillus subtilis surface display technology. This innovative platform, leveraging both spore and vegetative cell forms, provides exceptional versatility for a wide spectrum of applications, spanning from green technologies to advanced biomedical innovations. The robustness of spores and the metabolic activity of vegetative cells enable efficient enzyme immobilization, biocatalysis, and biosensor development, facilitating bioremediation, pollutant degradation, and renewable energy generation. Additionally, B. subtilis surface display systems have demonstrated remarkable potential in vaccine development and drug delivery, offering a cost-effective, scalable, and environmentally sustainable alternative to traditional methods. These systems can effectively present antigens or therapeutic molecules, enabling targeted drug delivery and robust immune responses. This review explores recent advancements, challenges, and opportunities in harnessing B. subtilis surface display technology for sustainable biomanufacturing, green innovations, and transformative biomedical applications, emphasizing its role in addressing pressing global challenges in environmental sustainability and healthcare.https://doi.org/10.1186/s13068-025-02635-4Bacillus subtilisSurface display technologySustainable biomanufacturingEnvironmental biotechnologyVaccine development |
| spellingShingle | Howra Bahrulolum Gholamreza Ahmadian Bacillus subtilis surface display technology: applications in bioprocessing and sustainable manufacturing Biotechnology for Biofuels and Bioproducts Bacillus subtilis Surface display technology Sustainable biomanufacturing Environmental biotechnology Vaccine development |
| title | Bacillus subtilis surface display technology: applications in bioprocessing and sustainable manufacturing |
| title_full | Bacillus subtilis surface display technology: applications in bioprocessing and sustainable manufacturing |
| title_fullStr | Bacillus subtilis surface display technology: applications in bioprocessing and sustainable manufacturing |
| title_full_unstemmed | Bacillus subtilis surface display technology: applications in bioprocessing and sustainable manufacturing |
| title_short | Bacillus subtilis surface display technology: applications in bioprocessing and sustainable manufacturing |
| title_sort | bacillus subtilis surface display technology applications in bioprocessing and sustainable manufacturing |
| topic | Bacillus subtilis Surface display technology Sustainable biomanufacturing Environmental biotechnology Vaccine development |
| url | https://doi.org/10.1186/s13068-025-02635-4 |
| work_keys_str_mv | AT howrabahrulolum bacillussubtilissurfacedisplaytechnologyapplicationsinbioprocessingandsustainablemanufacturing AT gholamrezaahmadian bacillussubtilissurfacedisplaytechnologyapplicationsinbioprocessingandsustainablemanufacturing |